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Displaying record number 58382

HXB2 Location  Gag(26-40)   Gag Epitope Map
View variants at this location
Epitope KKHYMLKHIVWASRE   Epitope Alignment
Variants
KKHYMLKHlVWASRE   subtype-specific susceptible form
{g}KKkYkLKHlVWASR   subtype-specific non-susceptible form
KKkYrLKHlVWASRE   subtype-specific non-susceptible form
KKkYrLKHlVWASRE   subtype-specific non-susceptible form
Epitope Name Peptide 7
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  2899
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKHYMLKHlVWASRE
Mutations I/L
Epitope Location I9L
HXB2 Location I34L
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Chinese Clade-C peptide 7, KKHYMLKHlVWASRE, cross reacted to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2900
Epitope Seq.  {x}KKHYMLKHIVWASRE
Variant Seq.  {g}KKkYkLKHlVWASR
Mutations x/G I/L H/K M/K
Epitope Location x1G I10L H4K M6K
HXB2 Location x26G I35L H29K M31K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-B peptide 7, {g}KKkYkLKHlVWASR, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2903
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKkYrLKHlVWASRE
Mutations H/K M/R I/L
Epitope Location H3K M5R I9L
HXB2 Location H28K M30R I34L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-A peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.


Variant ID.  2904
Epitope Seq.  KKHYMLKHIVWASRE
Variant Seq.  KKkYrLKHlVWASRE
Mutations H/K M/R I/L
Epitope Location H3K M5R I9L
HXB2 Location H28K M30R I34L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Sequence
Note Consensus Clade-D peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.


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