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Displaying record number 58382

HXB2 Location Gag(26-40) Gag Epitope Map
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KKHYMLKHIVWASRE

`KKHYMLKHlVWASRE`		subtype-specific susceptible form
`{g}KKkYkLKHlVWASR`		subtype-specific non-susceptible form
`KKkYrLKHlVWASRE`		subtype-specific non-susceptible form
`KKkYrLKHlVWASRE`		subtype-specific non-susceptible form

Epitope Name Peptide 7

Species (MHC/HLA) human

Variant Details

Showing all: 4 variant(s).

Variant ID.	`2899`
Epitope Seq.	`KKHYMLKHIVWASRE`
Variant Seq.	`KKHYMLKHlVWASRE`
Mutations	I/L
Epitope Location	I9L
HXB2 Location	I34L
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Chinese Clade-C peptide 7, KKHYMLKHlVWASRE, cross reacted to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2900`
Epitope Seq.	`{x}KKHYMLKHIVWASRE`
Variant Seq.	`{g}KKkYkLKHlVWASR`
Mutations	x/G I/L H/K M/K
Epitope Location	x1G I10L H4K M6K
HXB2 Location	x26G I35L H29K M31K
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-B peptide 7, {g}KKkYkLKHlVWASR, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2903`
Epitope Seq.	`KKHYMLKHIVWASRE`
Variant Seq.	`KKkYrLKHlVWASRE`
Mutations	H/K M/R I/L
Epitope Location	H3K M5R I9L
HXB2 Location	H28K M30R I34L
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	A
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-A peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

Variant ID.	`2904`
Epitope Seq.	`KKHYMLKHIVWASRE`
Variant Seq.	`KKkYrLKHlVWASRE`
Mutations	H/K M/R I/L
Epitope Location	H3K M5R I9L
HXB2 Location	H28K M30R I34L
Mutation Type	SNSF: subtype-specific non-susceptible form
Epitope Subtype	C
Variant Subtype	D
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Consensus Clade-D peptide 7, KKkYrLKHlVWASRE, did not cross react to elicit a response from South African subjects carrying clade-C virus.

References

Zembe2011 Lycias Zembe, Wendy A. Burgers, Heather B. Jaspan, Linda-Gail Bekker, Helba Bredell, Gwynneth Stevens, Jill Gilmour, Josephine H. Cox, Patricia Fast, Peter Hayes, Eftyhia Vardas, Carolyn Williamson, and Clive M. Gray. Intra- and Inter-Clade Cross-Reactivity by HIV-1 Gag Specific T-Cells Reveals Exclusive and Commonly Targeted Regions: Implications for Current Vaccine Trials. PLoS One, 6(10):e26096, 2011. PubMed ID: 22022524. Show all entries for this paper.