logo image

HIV Molecular Immunology Database

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 58232

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   inferred escape
xSPRTLNAW   inferred escape
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2799
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type IE: inferred escape
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/3 or 2/3 sequences of epitope ISPRTLNAW varied at 350 DFOSx to lSPRTLNAW and xSPRTLNAW, where X = l or s. Position 15 in the epitope is marked as being under selection to vary.


Variant ID.  2800
Epitope Seq.  ISPRTLNAW
Variant Seq.  xSPRTLNAW
Mutations I/X
Epitope Location I1X
HXB2 Location I147X
Mutation Type IE: inferred escape
Epitope Subtype B
Variant Subtype B
Method Sequence
Note 1/3 or 2/3 sequences of epitope ISPRTLNAW varied at 350 DFOSx to xSPRTLNAW, since x = l or s, and another variant, lSPRTLNAW is found. Position 15 in the epitope is marked as being under selection to vary.

References

Ferrari2011 Guido Ferrari, Bette Korber, Nilu Goonetilleke, Michael K. P. Liu, Emma L. Turnbull, Jesus F. Salazar-Gonzalez, Natalie Hawkins, Steve Self, Sydeaka Watson, Michael R. Betts, Cynthia Gay, Kara McGhee, Pierre Pellegrino, Ian Williams, Georgia D. Tomaras, Barton F. Haynes, Clive M. Gray, Persephone Borrow, Mario Roederer, Andrew J. McMichael, and Kent J. Weinhold. Relationship between Functional Profile of HIV-1 Specific CD8 T Cells and Epitope Variability with the Selection of Escape Mutants in Acute HIV-1 Infection. PLoS Pathog., 7(2):e1001273, 2011. PubMed ID: 21347345. Show all entries for this paper.


This is a legacy search page. It is deprecated, will receive no more updates, and will eventually be removed. Please use the new search pages.

Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy's National Nuclear Security Administration
Copyright Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services LANL logo National Institutes of Health logo