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Found 1 matching record:

Displaying record number 57682

HXB2 Location  Gag(20-29)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKKY   Epitope Alignment
Variants
RLRPGGKKhY   susceptible form; subtype-specific susceptible form
RLRPGGKKrY   susceptible form; subtype-specific susceptible form
RLRPGGKKqY   susceptible form; subtype-specific susceptible form
qLRPGGKKrY   susceptible form; subtype-specific susceptible form
Epitope Name EnvRY10
Species (MHC/HLA human(A3)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2678
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKhY
Mutations K/H
Epitope Location K9H
HXB2 Location K28H
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RLRPGGKKhY was found at frequencies of 2 and 48 in clades B and C respectively.


Variant ID.  2679
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKrY
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RLRPGGKKrY was found at frequencies of 9 and 14 in clades B and C respectively.


Variant ID.  2680
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKqY
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RLRPGGKKqY was found at frequencies of 5, 11, 8 and 5 in clades A, B, C and D respectively.


Variant ID.  2681
Epitope Seq.  RLRPGGKKKY
Variant Seq.  qLRPGGKKrY
Mutations R/Q K/R
Epitope Location R1Q K9R
HXB2 Location R20Q K28R
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant qLRPGGKKrY was found at a frequency of 23 in clade D.

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


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