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Displaying record number 57416

HXB2 Location Gag(162-172) Gag Epitope Map
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KAFSPEVIPMF

`KnFSPEVIPMF`		diminished HLA binding or increased off-rate; literature escape
`rAFSPEiIPMF`		diminished HLA binding or increased off-rate; literature escape

Epitope Name KF11

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`2363`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KnFSPEVIPMF`
Mutations	A/N
Epitope Location	A2N
HXB2 Location	A163N
Mutation Type	DHB: diminished HLA binding or increased off-rate LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Controller subject CH-22 had the A163X escape that has a fitness cost. CH-22 lacked the partially compensating mutation S165X, however. Variant A163N was recognized with a lower avidity than wild type KF11.

Variant ID.	`2364`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`rAFSPEiIPMF`
Mutations	K/R V/I
Epitope Location	K1R V7I
HXB2 Location	K162R V168I
Mutation Type	DHB: diminished HLA binding or increased off-rate LE: literature escape
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	This rare escape was seen in subject CH-13, a controller. CH-13 also displayed a rare substitution in epitope TW10 (TSTLQEQIGW), suggesting that the two rare mutational pathways may be inter-dependent. Avidity of this variant, rAFSPEiIPMF, was much lower than that of wild type KF11.

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.