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Found 1 matching record:

Displaying record number 57415

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   literature escape
{p}lSPRTLNAW   observed variant
{p}ISPRTLNAW   literature escape; processing
Epitope Name ISW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2360
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I2L
HXB2 Location I147L
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Sequence
Note This 147L mutation was more common in progressors than controllers.


Variant ID.  2361
Epitope Seq.  {A}ISPRTLNAW
Variant Seq.  {p}lSPRTLNAW
Mutations A/P I/L
Epitope Location A1P I2L
HXB2 Location A146P I147L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This double mutation was seen in one progressor, CH-01 and one controller, CH-04.


Variant ID.  2362
Epitope Seq.  {A}ISPRTLNAW
Variant Seq.  {p}ISPRTLNAW
Mutations A/P
Epitope Location A1P
HXB2 Location A146P
Mutation Type LE: literature escape
P: processing
Epitope Subtype B
Variant Subtype B
Method Sequence
Note This antigen processing escape, 146P, was more common in controllers than progressors.

References

Tang2010 Yanhua Tang, Sihong Huang, Jacqueline Dunkley-Thompson, Julianne C. Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, Celia D. C. Christie, and Margaret E. Feeney. Correlates of Spontaneous Viral Control among Long-Term Survivors of Perinatal HIV-1 Infection Expressing Human Leukocyte Antigen-B57. AIDS, 24(10):1425-1435, 19 Jun 2010. PubMed ID: 20539088. Show all entries for this paper.


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