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Displaying record number 56630

HXB2 Location Gag(147-155) Gag Epitope Map
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Epitope

ISPRTLNAW

Epitope Alignment

Variants

lSPRTLNAW escape documented in this paper

Epitope Name IW9

Species (MHC/HLA) human(B*57:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1980`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	E: escape documented in this paper
Method	CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Sequence
Note	A simple but atypical pattern of escape was seen with this variant in one patient, CH77 where the variant completely replaced the index epitope. In patient CH58, no significant change with respect to selection in this epitope was detected. For CH58, positive ELISpot from the full proteome scan but with not statistical evidence for selection for change was seen. For CH77, known T cell response from the full proteome scan with evidence for variation and escape by positive ELISpot was seen.

References

Goonetilleke2009 Nilu Goonetilleke, Michael K. P. Liu, Jesus F. Salazar-Gonzalez, Guido Ferrari, Elena Giorgi, Vitaly V. Ganusov, Brandon F. Keele, Gerald H. Learn, Emma L. Turnbull, Maria G Salazar, Kent J Weinhold, Stephen Moore, CHAVI Clinical Core B, Norman Letvin, Barton F. Haynes, Myron S. Cohen, Peter Hraber, Tanmoy Bhattacharya, Persephone Borrow, Alan S. Perelson, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, and Andrew J. McMichael. The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection. J. Exp. Med., 206(6):1253-1272, 8 Jun 2009. PubMed ID: 19487423. Show all entries for this paper.