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Displaying record number 55700

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLYNTiATL`		susceptible form
`SLfNTVATL`		susceptible form
`SLfNTVAvL`		susceptible form
`SLfNTiAvL`		susceptible form
`SLhNTVATL`		escape documented in this paper; TCR related mutation
`SLYaaaAaL`		susceptible form

Epitope Name SL9

Species (MHC/HLA) human(A*02)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`1830`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	SF: susceptible form
Method	Sequence, TCR binding
Note	This natural variant was found in 1/12 proviruses of patient 868 and bound isolated wild type TCR with high affinity. High-affinity, mutated a11b6 TCR also bound this variant.

Variant ID.	`1831`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	SF: susceptible form
Method	Intracellular cytokine staining, Sequence, TCR binding
Note	This naturally occurring variant was recognized by a CTL line from patient 868. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response.

Variant ID.	`1832`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVAvL`
Mutations	Y/F T/V
Epitope Location	Y3F T8V
HXB2 Location	Y79F T84V
Mutation Type	SF: susceptible form
Method	Intracellular cytokine staining, Sequence, TCR binding
Note	This naturally occurring variant was recognized by a CTL line from patient 868. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response, though this binding was the weakest of all variants tested.

Variant ID.	`1833`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiAvL`
Mutations	Y/F V/I T/V
Epitope Location	Y3F V6I T8V
HXB2 Location	Y79F V82I T84V
Mutation Type	SF: susceptible form
Method	Intracellular cytokine staining, Sequence, TCR binding
Note	This naturally occurring variant was recognized by a CTL line from patient 868 and found in 11/12 sequenced proviruses. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response.

Variant ID.	`1834`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLhNTVATL`
Mutations	Y/H
Epitope Location	Y3H
HXB2 Location	Y79H
Mutation Type	E: escape documented in this paper TCR: TCR related mutation
Method	Sequence, Surface Plasmon Resonance, TCR binding
Note	This unusual SL9 escape variant was recognized poorly by patient 868 CTL, suggesting that viruses with this mutation would escape wild type TCR recognition. High affinity a11b6 TCR, however, did bind this variant well enough by surface plasmon resonance to predict recognition.

Variant ID.	`2279`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYaaaAaL`
Mutations	N/A T/A V/A T/A
Epitope Location	N4A T5A V6A T8A
HXB2 Location	N80A T81A V82A T84A
Mutation Type	SF: susceptible form
Method	TCR binding
Note	A patient 868 CTL line showed some recognition of this multiply substituted peptide.

References

Varela-Rohena2008 Angel Varela-Rohena, Peter E. Molloy, Steven M. Dunn, Yi Li, Megan M. Suhoski, Richard G. Carroll, Anita Milicic, Tara Mahon, Deborah H. Sutton, Bruno Laugel, Ruth Moysey, Brian J. Cameron, Annelise Vuidepot, Marco A. Purbhoo, David K. Cole, Rodney E. Phillips, Carl H. June, Bent K. Jakobsen, Andrew K. Sewell, and James L. Riley. Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-Cell Receptor. Nat. Med., 14(12):1390-1385, Dec 2008. PubMed ID: 18997777. Show all entries for this paper.