HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 55700

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiATL   susceptible form
SLfNTVATL   susceptible form
SLfNTVAvL   susceptible form
SLfNTiAvL   susceptible form
SLhNTVATL   escape documented in this paper; TCR related mutation
SLYaaaAaL   susceptible form
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 6 variant(s).


Variant ID.  1830
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type SF: susceptible form
Method Sequence, TCR binding
Note This natural variant was found in 1/12 proviruses of patient 868 and bound isolated wild type TCR with high affinity. High-affinity, mutated a11b6 TCR also bound this variant.


Variant ID.  1831
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type SF: susceptible form
Method Intracellular cytokine staining, Sequence, TCR binding
Note This naturally occurring variant was recognized by a CTL line from patient 868. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response.


Variant ID.  1832
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type SF: susceptible form
Method Intracellular cytokine staining, Sequence, TCR binding
Note This naturally occurring variant was recognized by a CTL line from patient 868. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response, though this binding was the weakest of all variants tested.


Variant ID.  1833
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAvL
Mutations Y/F V/I T/V
Epitope Location Y3F V6I T8V
HXB2 Location Y79F V82I T84V
Mutation Type SF: susceptible form
Method Intracellular cytokine staining, Sequence, TCR binding
Note This naturally occurring variant was recognized by a CTL line from patient 868 and found in 11/12 sequenced proviruses. Wild type 868 TCR also bound this variant. Binding to high-affinity TCR (a11b6) increased the magnitude of cytokine response.


Variant ID.  1834
Epitope Seq.  SLYNTVATL
Variant Seq.  SLhNTVATL
Mutations Y/H
Epitope Location Y3H
HXB2 Location Y79H
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Method Sequence, Surface Plasmon Resonance, TCR binding
Note This unusual SL9 escape variant was recognized poorly by patient 868 CTL, suggesting that viruses with this mutation would escape wild type TCR recognition. High affinity a11b6 TCR, however, did bind this variant well enough by surface plasmon resonance to predict recognition.


Variant ID.  2279
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYaaaAaL
Mutations N/A T/A V/A T/A
Epitope Location N4A T5A V6A T8A
HXB2 Location N80A T81A V82A T84A
Mutation Type SF: susceptible form
Method TCR binding
Note A patient 868 CTL line showed some recognition of this multiply substituted peptide.

References

Varela-Rohena2008 Angel Varela-Rohena, Peter E. Molloy, Steven M. Dunn, Yi Li, Megan M. Suhoski, Richard G. Carroll, Anita Milicic, Tara Mahon, Deborah H. Sutton, Bruno Laugel, Ruth Moysey, Brian J. Cameron, Annelise Vuidepot, Marco A. Purbhoo, David K. Cole, Rodney E. Phillips, Carl H. June, Bent K. Jakobsen, Andrew K. Sewell, and James L. Riley. Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-Cell Receptor. Nat. Med., 14(12):1390-1385, Dec 2008. PubMed ID: 18997777. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health