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Displaying record number 55068

HXB2 Location Gag(156-164) Gag Epitope Map
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Epitope

VKVVEEKAF

Epitope Alignment

Variants

VKViEEKAF subtype-specific susceptible form

Species (MHC/HLA) human(B*15:03)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`213`
Epitope Seq.	`VKVVEEKAF`
Variant Seq.	`VKViEEKAF`
Mutations	V/I
Epitope Location	V4I
HXB2 Location	V159I
Mutation Type	SSF: subtype-specific susceptible form
Epitope Subtype	B
Variant Subtype	C
Note	VKVVEEKAF epitope is found in subtype B, while the variant is found in subtype C. Both are frequently targeted by B*1503 positive individuals.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.