HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 55068

HXB2 Location  Gag(156-164)   Gag Epitope Map
View variants at this location
Epitope VKVVEEKAF   Epitope Alignment
Variants
VKViEEKAF   subtype-specific susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  213
Epitope Seq.  VKVVEEKAF
Variant Seq.  VKViEEKAF
Mutations V/I
Epitope Location V4I
HXB2 Location V159I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Note VKVVEEKAF epitope is found in subtype B, while the variant is found in subtype C. Both are frequently targeted by B*1503 positive individuals.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health