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Found 1 matching record:

Displaying record number 55064

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTVAvL   diminished response
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  183
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. SLYNTVAvL variant arose in one twin and not the other. Response to the variant was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


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