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Found 1 matching record:

Displaying record number 55053

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFnPEVIPMF   subtype-specific non-susceptible form; subtype-specific susceptible form
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  143
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, C, D
Variant Subtype A
Note KAFSPEVIPMF within peptide EKAFSPEVIPMFSAL from A consensus, C isolate and D isolate was recognized by 5/5 HLA B*5701/B*5703 carriers from subtype A Kenyan cohort. The variant KgFnPEVIPMF within peptide EKgFnPEVIPMFSAL from A isolate was recognized by 3 out 5 subjects that recognized KAFSPEVIPMF and not recognized by 2 subjects.

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


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