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Found 1 matching record:

Displaying record number 55001

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
rAFSPEVIPMF   susceptible form
KnFSPEVIPMF   non-susceptible form; susceptible form
KgFSPEVIPMF   susceptible form
KAFSPEiIPMF   susceptible form
KAFnPEVIPMF   non-susceptible form; susceptible form
KgFnPEVIPMF   non-susceptible form; susceptible form
KAFnPEiIPMF   non-susceptible form; susceptible form
KAFSPgVIPMF   non-susceptible form
Epitope Name KAF
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 8 variant(s).


Variant ID.  1797
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  rAFSPEVIPMF
Mutations K/R
Epitope Location K1R
HXB2 Location K162R
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note This natural variant was recognized in all patients tested.


Variant ID.  1798
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note About half of patients tested recognized the variant, other patients had reduced or no response.


Variant ID.  1799
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note All patients recognized the variant at >60% of the response to the index peptide.


Variant ID.  1800
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEiIPMF
Mutations V/I
Epitope Location V7I
HXB2 Location V168I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note All patients recognized the variant at >60% of the response to the index peptide.


Variant ID.  1801
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEVIPMF
Mutations S/N
Epitope Location S4N
HXB2 Location S165N
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note About half of patients tested recognized the variant, other patients had reduced or no response.


Variant ID.  1802
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note 2 patients had response about 80% of the response to the index peptide. Most patients had reduced or no response.


Variant ID.  1803
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEiIPMF
Mutations S/N V/I
Epitope Location S4N V7I
HXB2 Location S165N V168I
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note 1 patient had response comparable to the response to the index peptide. Most patients had reduced or no response.


Variant ID.  1804
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPgVIPMF
Mutations E/G
Epitope Location E6G
HXB2 Location E167G
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Tetramer binding
Note None of the patients tested responded to this variant.

References

Turnbull2006 Emma L. Turnbull, A. Ross Lopes, Nicola A. Jones, David Cornforth, Phillipa Newton, Diana Aldam, Pierre Pellegrino, Jo Turner, Ian Williams, Craig M. Wilson, Paul A. Goepfert, Mala K. Maini, and Persephone Borrow. HIV-1 Epitope-Specific CD8+ T Cell Responses Strongly Associated with Delayed Disease Progression Cross-Recognize Epitope Variants Efficiently. J. Immunol., 176(10):6130-6146, 15 May 2006. PubMed ID: 16670322. Show all entries for this paper.


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