HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 54629

HXB2 Location  Gag(17-34)   Gag Epitope Map
View variants at this location
Epitope EKIRLRPGGKKKYRLKHL   Epitope Alignment
Variants
EKIRLRPGGKKhYmLKHL   subtype-specific susceptible form
Epitope Name GAG-03
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1957
Epitope Seq.  EKIRLRPGGKKKYRLKHL
Variant Seq.  EKIRLRPGGKKhYmLKHL
Mutations K/H R/M
Epitope Location K12H R14M
HXB2 Location K28H R30M
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note This Clade C consensus synthetic peptide variant from an immunodominant region, differs from the immunodominant Clade B consensus at 2 amino acids (11.1%) and both were recognized by subtype-B-infected subjects.

References

Zhao2007 Shuguang Zhao, Song Zhai, Yan Zhuang, Shaoyang Wang, Dedong Huang, Whenzhen Kang, Xinhong Li, Xu G. Yu, Bruce D. Walker, Marcus A. Altfeld, and Yongtao Sun. Inter-Clade Cross-Reactivity of HIV-1-Specific T Cell Responses in Human Immunodeficiency Virus Type 1 Infection in China. Curr. HIV Res., 5(2):251-259, Mar 2007. PubMed ID: 17346138. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health