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Displaying record number 54598

HXB2 Location Gag(147-155) Gag Epitope Map
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Epitope

ISPRTLNAW

Epitope Alignment

Variants

lSPRTLNAW diminished response

Species (MHC/HLA) human(B57, B58)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`342`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	DR: diminished response
Epitope Subtype	C
Variant Subtype	A, D
Note	The wild type epitope sequence was a subtype C peptide, the variant common to subtypes A and D. CTL response in 56 individuals from Tanzania was strongest for subtypes A and D peptides, and much lower for subtype C, due to point mutation and/or frame-of-epitope effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.