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Displaying record number 54594

HXB2 Location Gag(180-188) Gag Epitope Map
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Epitope

TPQDLNTML

Epitope Alignment

Variants

TPQDLNmML diminished response

Species (MHC/HLA) human(B42, B7, B81)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`343`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPQDLNmML`
Mutations	T/M
Epitope Location	T7M
HXB2 Location	T186M
Mutation Type	DR: diminished response
Epitope Subtype	C, D
Variant Subtype	A
Note	The wild type epitope sequence was common to subtypes C and D, the variant to subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and much lower for subtype A, due to point mutation effect. The response was also lower for subtype D, due to frame-of-epitope effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.