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Displaying record number 54497

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLYNTVAaL`		susceptible form
`lLYNTVATL`		susceptible form
`SLYNTVAsL`		susceptible form
`SLYNTpATL`		susceptible form
`lLYNTVAaL`		susceptible form
`lLYNTVAsL`		susceptible form
`lLYNTVlTL`		susceptible form
`SLYNTsAaL`		susceptible form
`lLYNTpATL`		susceptible form
`SLYNTpAaL`		susceptible form
`SLYNTpAsL`		susceptible form
`SLhNwslaL`		susceptible form
`SLwNwplaL`		susceptible form
`SLwNwplsL`		susceptible form
`SLhNwplaL`		susceptible form
`SLhNwplsL`		susceptible form
`lLwNTslaL`		susceptible form
`lLwNwslaL`		susceptible form
`lLwNwslsL`		susceptible form
`lLwNwplaL`		susceptible form
`lLhNwslaL`		susceptible form
`lLhNwplsL`		susceptible form
`SLfNTVATL`		escape documented in this paper; susceptible form
`SLfNTVAvL`		diminished response; escape documented in this paper
`SLfNTiAvL`		escape documented in this paper; susceptible form
`SLYNTiATL`		diminished response; susceptible form
`SLYNTiAvL`		diminished response; susceptible form
`SvYNTVATL`		diminished response; susceptible form
`SLYNTVAvL`		diminished response; susceptible form

Epitope Name SL9

Species (MHC/HLA) human, mouse(A2)

Variant Details

Showing all: 29 variant(s).

Variant ID.	`596`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T84A
Mutation Type	SF: susceptible form
Note	This synthesized variant was recognized by CTLs from 8/9 individuals. The variant was more immunogenic than the wt, reduced IL-2-mediated activation induced cell death that the wt CTLs were susceptible to, and induced broad response to several SL9 variants.

Variant ID.	`597`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLYNTVATL`
Mutations	S/L
Epitope Location	S1L
HXB2 Location	S77L
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 6/8 donors.

Variant ID.	`598`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAsL`
Mutations	T/S
Epitope Location	T8S
HXB2 Location	T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 7/8 donors.

Variant ID.	`599`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTpATL`
Mutations	V/P
Epitope Location	V6P
HXB2 Location	V82P
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`600`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLYNTVAaL`
Mutations	S/L T/A
Epitope Location	S1L T8A
HXB2 Location	S77L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 5/8 donors.

Variant ID.	`601`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLYNTVAsL`
Mutations	S/L T/S
Epitope Location	S1L T8S
HXB2 Location	S77L T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 6/8 donors.

Variant ID.	`602`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLYNTVlTL`
Mutations	S/L A/L
Epitope Location	S1L A7L
HXB2 Location	S77L A83L
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 2/8 donors.

Variant ID.	`603`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTsAaL`
Mutations	V/S T/A
Epitope Location	V6S T8A
HXB2 Location	V82S T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`604`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLYNTpATL`
Mutations	S/L V/P
Epitope Location	S1L V6P
HXB2 Location	S77L V82P
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`605`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTpAaL`
Mutations	V/P T/A
Epitope Location	V6P T8A
HXB2 Location	V82P T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`606`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTpAsL`
Mutations	V/P T/S
Epitope Location	V6P T8S
HXB2 Location	V82P T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 2/8 donors.

Variant ID.	`607`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLhNwslaL`
Mutations	Y/H T/W V/S A/L T/A
Epitope Location	Y3H T5W V6S A7L T8A
HXB2 Location	Y79H T81W V82S A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`608`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLwNwplaL`
Mutations	Y/W T/W V/P A/L T/A
Epitope Location	Y3W T5W V6P A7L T8A
HXB2 Location	Y79W T81W V82P A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`609`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLwNwplsL`
Mutations	Y/W T/W V/P A/L T/S
Epitope Location	Y3W T5W V6P A7L T8S
HXB2 Location	Y79W T81W V82P A83L T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`610`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLhNwplaL`
Mutations	Y/H T/W V/P A/L T/A
Epitope Location	Y3H T5W V6P A7L T8A
HXB2 Location	Y79H T81W V82P A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`611`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLhNwplsL`
Mutations	Y/H T/W V/P A/L T/S
Epitope Location	Y3H T5W V6P A7L T8S
HXB2 Location	Y79H T81W V82P A83L T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`612`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLwNTslaL`
Mutations	S/L Y/W V/S A/L T/A
Epitope Location	S1L Y3W V6S A7L T8A
HXB2 Location	S77L Y79W V82S A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.

Variant ID.	`613`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLwNwslaL`
Mutations	S/L Y/W T/W V/S A/L T/A
Epitope Location	S1L Y3W T5W V6S A7L T8A
HXB2 Location	S77L Y79W T81W V82S A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 2/8 donors.

Variant ID.	`614`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLwNwslsL`
Mutations	S/L Y/W T/W V/S A/L T/S
Epitope Location	S1L Y3W T5W V6S A7L T8S
HXB2 Location	S77L Y79W T81W V82S A83L T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`615`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLwNwplaL`
Mutations	S/L Y/W T/W V/P A/L T/A
Epitope Location	S1L Y3W T5W V6P A7L T8A
HXB2 Location	S77L Y79W T81W V82P A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`616`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLhNwslaL`
Mutations	S/L Y/H T/W V/S A/L T/A
Epitope Location	S1L Y3H T5W V6S A7L T8A
HXB2 Location	S77L Y79H T81W V82S A83L T84A
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`617`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`lLhNwplsL`
Mutations	S/L Y/H T/W V/P A/L T/S
Epitope Location	S1L Y3H T5W V6P A7L T8S
HXB2 Location	S77L Y79H T81W V82P A83L T84S
Mutation Type	SF: susceptible form
Note	74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.

Variant ID.	`618`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	E: escape documented in this paper SF: susceptible form
Note	This variant was not recognized by SL9-CTLs from one patient while it was recognized by the T/A-variant CTLs from this patient and by SL9- and T/A-CTLs derived from sister cells from another patient.

Variant ID.	`619`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVAvL`
Mutations	Y/F T/V
Epitope Location	Y3F T8V
HXB2 Location	Y79F T84V
Mutation Type	DR: diminished response E: escape documented in this paper
Note	This variant was not recognized by SL9-CTLs from one patient while it was recognized by the T/A-variant CTLs from this patient and by SL9- and T/A-CTLs derived from sister cells from another patient. It was recognized to a lesser extent than the wt.

Variant ID.	`620`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiAvL`
Mutations	Y/F V/I T/V
Epitope Location	Y3F V6I T8V
HXB2 Location	Y79F V82I T84V
Mutation Type	E: escape documented in this paper SF: susceptible form
Note	This variant was not recognized by SL9-CTLs from one patient while it was recognized by the T/A-variant CTLs from this patient and by SL9- and T/A-CTLs derived from sister cells from another patient.

Variant ID.	`621`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	DR: diminished response SF: susceptible form
Note	This variant was recognized by SL9-CTLs from one patient while it was recognized to a lesser extent by the T/A-variant CTLs from this patient. It was recognized by SL9- and T/A-CTLs derived from sister cells from another patient.

Variant ID.	`622`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiAvL`
Mutations	V/I T/V
Epitope Location	V6I T8V
HXB2 Location	V82I T84V
Mutation Type	DR: diminished response SF: susceptible form
Note	This variant was recognized by SL9-CTLs from one patient while it was recognized to a lesser extent by the T/A-variant CTLs from this patient. It was recognized by SL9- and T/A-CTLs derived from sister cells from another patient.

Variant ID.	`623`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SvYNTVATL`
Mutations	L/V
Epitope Location	L2V
HXB2 Location	L78V
Mutation Type	DR: diminished response SF: susceptible form
Note	This variant was recognized by both SL9-CTLs and by the T/A-variant CTLs from this patient, but to somewhat lesser extent than the wt epitope. It was also recognized by SL9- and T/A-CTLs derived from sister cells from another patient.

Variant ID.	`2256`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAvL`
Mutations	T/V
Epitope Location	T8V
HXB2 Location	T84V
Mutation Type	DR: diminished response SF: susceptible form
Note	This variant was recognized by both SL9-CTLs and by the T/A-variant CTLs from two patients, but to somewhat lesser extent than the wt epitope in one of the patients.

References

Kan-Mitchell2006 June Kan-Mitchell, Melissa Bajcz, Keri L. Schaubert, David A. Price, Jason M. Brenchley, Tedi E. Asher, Daniel C. Douek, Hwee L. Ng, Otto O. Yang, Charles R. Rinaldo, Jr., Jose Miguel Benito, Brygida Bisikirska, Ramakrishna Hegde, Franco M. Marincola, César Boggiano, Dianne Wilson, Judith Abrams, Sylvie E. Blondelle, and Darcy B. Wilson. Degeneracy and Repertoire of the Human HIV-1 Gag p17(77-85) CTL Response. J. Immunol., 176(11):6690-6701, 1 Jun 2006. PubMed ID: 16709828. Show all entries for this paper.