HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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| Epitope |
TPQDLNTML
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Epitope Alignment | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Variants |
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| Epitope Name | TL9 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species (MHC/HLA) | human | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Showing all: 20 variant(s).
| Variant ID. | 916 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLNsML |
| Mutations | T/S |
| Epitope Location | T7S |
| HXB2 Location | T186S |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Most common variant for B*4201, B*8101 and B*3910. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals. |
| Variant ID. | 917 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPtDLNTML |
| Mutations | Q/T |
| Epitope Location | Q3T |
| HXB2 Location | Q182T |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Variant found in B*8101, B*4201 and B*0702 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals. |
| Variant ID. | 918 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPsDLNTML |
| Mutations | Q/S |
| Epitope Location | Q3S |
| HXB2 Location | Q182S |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Variant found in B*8101 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals. |
| Variant ID. | 919 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPpDLNTML |
| Mutations | Q/P |
| Epitope Location | Q3P |
| HXB2 Location | Q182P |
| Mutation Type | OV: observed variant |
| Note | Variant found in B*4201 positive patients. |
| Variant ID. | 920 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPaDLNTML |
| Mutations | Q/A |
| Epitope Location | Q3A |
| HXB2 Location | Q182A |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Variant found in B*8101 and B*4201 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals. |
| Variant ID. | 921 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPvDLNTML |
| Mutations | Q/V |
| Epitope Location | Q3V |
| HXB2 Location | Q182V |
| Mutation Type | OV: observed variant |
| Note | Variant found in B*4201 positive patients. |
| Variant ID. | 922 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPhDLNTML |
| Mutations | Q/H |
| Epitope Location | Q3H |
| HXB2 Location | Q182H |
| Mutation Type | OV: observed variant |
| Note | Variant found in B*4201 positive patients. |
| Variant ID. | 923 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLNmML |
| Mutations | T/M |
| Epitope Location | T7M |
| HXB2 Location | T186M |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy |
| Note | Variant found in B*8101 and B*4201 positive patients. The variant was not recognized by CTLs from B*8101 and B*4201 positive individuals. |
| Variant ID. | 924 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TsQDLNTML |
| Mutations | P/S |
| Epitope Location | P2S |
| HXB2 Location | P181S |
| Mutation Type | OV: observed variant |
| Note | Variant found in B*8101 and B*4201 positive patients. |
| Variant ID. | 925 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPeDLNTML |
| Mutations | Q/E |
| Epitope Location | Q3E |
| HXB2 Location | Q182E |
| Mutation Type | OV: observed variant |
| Note | Variant found in 8% of B*4201 positive patients. |
| Variant ID. | 926 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPsDLNsML |
| Mutations | Q/S T/S |
| Epitope Location | Q3S T7S |
| HXB2 Location | Q182S T186S |
| Mutation Type | OV: observed variant |
| Note | Variant found in 6% of B*4201 positive patients. |
| Variant ID. | 927 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPgDLNTML |
| Mutations | Q/G |
| Epitope Location | Q3G |
| HXB2 Location | Q182G |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*4201 positive patients. |
| Variant ID. | 928 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | aPQDLNTMv |
| Mutations | T/A L/V |
| Epitope Location | T1A L9V |
| HXB2 Location | T180A L188V |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*4201 positive patients. |
| Variant ID. | 929 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | nPQDLNTML |
| Mutations | T/N |
| Epitope Location | T1N |
| HXB2 Location | T180N |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*4201 positive patients. |
| Variant ID. | 930 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPsDLNTMf |
| Mutations | Q/S L/F |
| Epitope Location | Q3S L9F |
| HXB2 Location | Q182S L188F |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*4201 positive patients. |
| Variant ID. | 931 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLyTML |
| Mutations | N/Y |
| Epitope Location | N6Y |
| HXB2 Location | N185Y |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*4201 positive patients. |
| Variant ID. | 932 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLNTfL |
| Mutations | M/F |
| Epitope Location | M8F |
| HXB2 Location | M187F |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*4201, and 2% of B*0702 positive patients. |
| Variant ID. | 933 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TPQDLNTvL |
| Mutations | M/V |
| Epitope Location | M8V |
| HXB2 Location | M187V |
| Mutation Type | OV: observed variant |
| Note | Variant found in 2% of B*0702 positive patients. |
| Variant ID. | 934 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | TqQDLNpML |
| Mutations | P/Q T/P |
| Epitope Location | P2Q T7P |
| HXB2 Location | P181Q T186P |
| Mutation Type | OV: observed variant |
| Note | Variant found in 6% of B*3910 positive patients. |
| Variant ID. | 935 |
|---|---|
| Epitope Seq. | TPQDLNTML |
| Variant Seq. | aPQDLNTML |
| Mutations | T/A |
| Epitope Location | T1A |
| HXB2 Location | T180A |
| Mutation Type | OV: observed variant |
| Note | Variant found in 6% of B*3910 positive patients. |
Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.