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Displaying record number 54192

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNsML   escape documented in this paper
TPtDLNTML   escape documented in this paper
TPsDLNTML   escape documented in this paper
TPpDLNTML   observed variant
TPaDLNTML   escape documented in this paper
TPvDLNTML   observed variant
TPhDLNTML   observed variant
TPQDLNmML   escape documented in this paper
TsQDLNTML   observed variant
TPeDLNTML   observed variant
TPsDLNsML   observed variant
TPgDLNTML   observed variant
aPQDLNTMv   observed variant
nPQDLNTML   observed variant
TPsDLNTMf   observed variant
TPQDLyTML   observed variant
TPQDLNTfL   observed variant
TPQDLNTvL   observed variant
TqQDLNpML   observed variant
aPQDLNTML   observed variant
Epitope Name TL9
Species (MHC/HLA human

Variant Details

Showing all: 20 variant(s).


Variant ID.  916
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNsML
Mutations T/S
Epitope Location T7S
HXB2 Location T186S
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Most common variant for B*4201, B*8101 and B*3910. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals.


Variant ID.  917
Epitope Seq.  TPQDLNTML
Variant Seq.  TPtDLNTML
Mutations Q/T
Epitope Location Q3T
HXB2 Location Q182T
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found in B*8101, B*4201 and B*0702 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals.


Variant ID.  918
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNTML
Mutations Q/S
Epitope Location Q3S
HXB2 Location Q182S
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found in B*8101 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals.


Variant ID.  919
Epitope Seq.  TPQDLNTML
Variant Seq.  TPpDLNTML
Mutations Q/P
Epitope Location Q3P
HXB2 Location Q182P
Mutation Type OV: observed variant
Note Variant found in B*4201 positive patients.


Variant ID.  920
Epitope Seq.  TPQDLNTML
Variant Seq.  TPaDLNTML
Mutations Q/A
Epitope Location Q3A
HXB2 Location Q182A
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found in B*8101 and B*4201 positive patients. The variant was less well recognized than the wt, or not recognized at all, by CTLs from B*8101 and B*4201 positive individuals.


Variant ID.  921
Epitope Seq.  TPQDLNTML
Variant Seq.  TPvDLNTML
Mutations Q/V
Epitope Location Q3V
HXB2 Location Q182V
Mutation Type OV: observed variant
Note Variant found in B*4201 positive patients.


Variant ID.  922
Epitope Seq.  TPQDLNTML
Variant Seq.  TPhDLNTML
Mutations Q/H
Epitope Location Q3H
HXB2 Location Q182H
Mutation Type OV: observed variant
Note Variant found in B*4201 positive patients.


Variant ID.  923
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNmML
Mutations T/M
Epitope Location T7M
HXB2 Location T186M
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy
Note Variant found in B*8101 and B*4201 positive patients. The variant was not recognized by CTLs from B*8101 and B*4201 positive individuals.


Variant ID.  924
Epitope Seq.  TPQDLNTML
Variant Seq.  TsQDLNTML
Mutations P/S
Epitope Location P2S
HXB2 Location P181S
Mutation Type OV: observed variant
Note Variant found in B*8101 and B*4201 positive patients.


Variant ID.  925
Epitope Seq.  TPQDLNTML
Variant Seq.  TPeDLNTML
Mutations Q/E
Epitope Location Q3E
HXB2 Location Q182E
Mutation Type OV: observed variant
Note Variant found in 8% of B*4201 positive patients.


Variant ID.  926
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNsML
Mutations Q/S T/S
Epitope Location Q3S T7S
HXB2 Location Q182S T186S
Mutation Type OV: observed variant
Note Variant found in 6% of B*4201 positive patients.


Variant ID.  927
Epitope Seq.  TPQDLNTML
Variant Seq.  TPgDLNTML
Mutations Q/G
Epitope Location Q3G
HXB2 Location Q182G
Mutation Type OV: observed variant
Note Variant found in 2% of B*4201 positive patients.


Variant ID.  928
Epitope Seq.  TPQDLNTML
Variant Seq.  aPQDLNTMv
Mutations T/A L/V
Epitope Location T1A L9V
HXB2 Location T180A L188V
Mutation Type OV: observed variant
Note Variant found in 2% of B*4201 positive patients.


Variant ID.  929
Epitope Seq.  TPQDLNTML
Variant Seq.  nPQDLNTML
Mutations T/N
Epitope Location T1N
HXB2 Location T180N
Mutation Type OV: observed variant
Note Variant found in 2% of B*4201 positive patients.


Variant ID.  930
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNTMf
Mutations Q/S L/F
Epitope Location Q3S L9F
HXB2 Location Q182S L188F
Mutation Type OV: observed variant
Note Variant found in 2% of B*4201 positive patients.


Variant ID.  931
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLyTML
Mutations N/Y
Epitope Location N6Y
HXB2 Location N185Y
Mutation Type OV: observed variant
Note Variant found in 2% of B*4201 positive patients.


Variant ID.  932
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNTfL
Mutations M/F
Epitope Location M8F
HXB2 Location M187F
Mutation Type OV: observed variant
Note Variant found in 2% of B*4201, and 2% of B*0702 positive patients.


Variant ID.  933
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNTvL
Mutations M/V
Epitope Location M8V
HXB2 Location M187V
Mutation Type OV: observed variant
Note Variant found in 2% of B*0702 positive patients.


Variant ID.  934
Epitope Seq.  TPQDLNTML
Variant Seq.  TqQDLNpML
Mutations P/Q T/P
Epitope Location P2Q T7P
HXB2 Location P181Q T186P
Mutation Type OV: observed variant
Note Variant found in 6% of B*3910 positive patients.


Variant ID.  935
Epitope Seq.  TPQDLNTML
Variant Seq.  aPQDLNTML
Mutations T/A
Epitope Location T1A
HXB2 Location T180A
Mutation Type OV: observed variant
Note Variant found in 6% of B*3910 positive patients.

References

Leslie2006 Alasdair Leslie, David A. Price, Pamela Mkhize, Karen Bishop, Almas Rathod, Cheryl Day, Hayley Crawford, Isobella Honeyborne, Tedi E. Asher, Graz Luzzi, Anne Edwards, Christine M. Rousseau, James I. Mullins, Gareth Tudor-Williams, Vas Novelli, Christian Brander, Daniel C. Douek, Photini Kiepiela, Bruce D. Walker, and Philip J. R. Goulder. Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype. J. Immunol., 177(7):4699-4708, 1 Oct 2006. PubMed ID: 16982909. Show all entries for this paper.


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