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Found 1 matching record:

Displaying record number 54147

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope ETINEEAAEW   Epitope Alignment
Variants
ETINdEAAEW   diminished response
Epitope Name EW10
Species (MHC/HLA human(A*25:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  956
Epitope Seq.  ETINEEAAEW
Variant Seq.  ETINdEAAEW
Mutations E/D
Epitope Location E5D
HXB2 Location E207D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Amino acid site in the 5th position potentially experienced positive selection. Wt form of the epitope was 27 times better recognized than the variant, making the variant a partial escape.

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.


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