HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 54145

HXB2 Location  Gag(145-155)   Gag Epitope Map
View variants at this location
Epitope QAISPRTLNAW   Epitope Alignment
QAlSPRTLNAW   diminished response
Epitope Name QW11
Species (MHC/HLA human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.  955
Variant Seq.  QAlSPRTLNAW
Mutations I/L
Epitope Location I3L
HXB2 Location I147L
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Amino acid site in the third position potentially experienced positive selection. Wt form of the epitope was 2.4 times better recognized than the variant.


Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.

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