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Displaying record number 54145

HXB2 Location Gag(145-155) Gag Epitope Map
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Epitope

QAISPRTLNAW

Epitope Alignment

Variants

QAlSPRTLNAW diminished response

Epitope Name QW11

Species (MHC/HLA) human(A*25:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`955`
Epitope Seq.	`QAISPRTLNAW`
Variant Seq.	`QAlSPRTLNAW`
Mutations	I/L
Epitope Location	I3L
HXB2 Location	I147L
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Amino acid site in the third position potentially experienced positive selection. Wt form of the epitope was 2.4 times better recognized than the variant.

References

Liu2006 Yi Liu, John McNevin, Jianhong Cao, Hong Zhao, Indira Genowati, Kim Wong, Sherry McLaughlin, Matthew D. McSweyn, Kurt Diem, Claire E. Stevens, Janine Maenza, Hongxia He, David C. Nickle, Daniel Shriner, Sarah E. Holte, Ann C. Collier, Lawrence Corey, M. Juliana McElrath, and James I. Mullins. Selection on the Human Immunodeficiency Virus Type 1 Proteome following Primary Infection. J. Virol., 80(19):9519-9529, Oct 2006. PubMed ID: 16973556. Show all entries for this paper.