HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 1 matching record:

Displaying record number 53844

HXB2 Location  Gag(11-19)   Gag Epitope Map
View variants at this location
Epitope GELDRWEKI   Epitope Alignment
Variants
GELDRWkKI   diminished response; literature escape
Epitope Name GI9
Species (MHC/HLA human(B*40)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1569
Epitope Seq.  GELDRWEKI
Variant Seq.  GELDRWkKI
Mutations E/K
Epitope Location E7K
HXB2 Location E17K
Mutation Type DR: diminished response
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-B40-carrying mother, M-1002, but was never detected in her non-HLA-B40-carrying infant, P-1031. Decreased recognition of the E17K variant relative to the index epitope was seen in the mother.

References

Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health