HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


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Displaying record number 53841

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope KYKLKHIVW   Epitope Alignment
qYKLKHIVW   escape documented in this paper; literature escape
Epitope Name QW9
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 1 variant(s).

Variant ID.  1574
Epitope Seq.  KYKLKHIVW
Variant Seq.  qYKLKHIVW
Mutations K/Q
Epitope Location K1Q
HXB2 Location K28Q
Mutation Type E: escape documented in this paper
LE: literature escape
Method CD8 T-cell Elispot - IFNy, Sequence
Note This variant from the HXB2 sequence was present in the restricting HLA-A24 allele carrying mother, M-1003, as well as her HLA-A24-carrying infant, P-1189. Decreased recognition of the variant was seen relative to wild type index epitope. This variant was still detected at 12 months of age in infant P-1189. While the mother could recognize index epitope QW9, but not this variant, infant P-1189 could not recognize either index or variant.


Sanchez-Merino2005 Victor Sanchez-Merino, Siwei Nie, and Katherine Luzuriaga. HIV-1-Specific CD8+ T Cell Responses and Viral Evolution in Women and Infants. J. Immunol., 175(10):6976-6986, 15 Nov 2005. PubMed ID: 16272358. Show all entries for this paper.

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