HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(93-101) | Gag Epitope Map
View variants at this location |
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| Epitope |
EVKDTKEAL
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Epitope Alignment | |||||||
| Variants |
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| Species (MHC/HLA) | human(B*08:01) | ||||||||
Showing all: 2 variant(s).
| Variant ID. | 1308 |
|---|---|
| Epitope Seq. | EVKDTKEAL |
| Variant Seq. | dVKgTKEAL |
| Mutations | E/D D/G |
| Epitope Location | E1D D4G |
| HXB2 Location | E93D D96G |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | This variant was found in Donor2 but not transmitted to Recipient2. The variant was not recognized by CTL. Both donor and recipient carried the restricting HLA-B*0801 allele |
| Variant ID. | 1309 |
|---|---|
| Epitope Seq. | EVKDTKEAL |
| Variant Seq. | dVKDTKEAL |
| Mutations | E/D |
| Epitope Location | E1D |
| HXB2 Location | E93D |
| Mutation Type | E: escape documented in this paper SF: susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | This variant was found in Donor2 and Recipient2 both of whom were restricting HLA-B*0801 carriers. The variant was not recognized by CTL in Donor2, but was recognized in Recipient2 from whom it was driven out de novo in time. |
Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.