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Found 1 matching record:

Displaying record number 53818

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGr   diminished HLA binding or increased off-rate
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1300
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGr
Mutations K/R
Epitope Location K9R
HXB2 Location K26R
Mutation Type DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note This variant was seen in Donor1 and Recipient1. It was not recognized by either subject and showed diminished binding to HLA. The restricting HLA-A*0301 was only carried in the Donor.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.


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