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Displaying record number 53818

HXB2 Location Gag(18-26) Gag Epitope Map
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Epitope

KIRLRPGGK

Epitope Alignment

Variants

KIRLRPGGr diminished HLA binding or increased off-rate

Species (MHC/HLA) human(A*03:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`1300`
Epitope Seq.	`KIRLRPGGK`
Variant Seq.	`KIRLRPGGr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K26R
Mutation Type	DHB: diminished HLA binding or increased off-rate
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	This variant was seen in Donor1 and Recipient1. It was not recognized by either subject and showed diminished binding to HLA. The restricting HLA-A*0301 was only carried in the Donor.

References

Milicic2005 Anita Milicic, Charles T. T. Edwards, Stéphane Hué, Julie Fox, Helen Brown, Tilly Pillay, Jan W. Drijfhout, Jonathan N. Weber, Edward C. Holmes, Sarah J. Fidler, Hua-Tang Zhang, and Rodney E. Phillips. Sexual Transmission of Single Human Immunodeficiency Virus Type 1 Virions Encoding Highly Polymorphic Multisite Cytotoxic T-Lymphocyte Escape Variants. J. Virol., 79(22):13953-13962, Nov 2005. PubMed ID: 16254331. Show all entries for this paper.