HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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| Epitope |
KAFSPEVIPMF
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Epitope Alignment | ||||||||||||||||||||||
| Variants |
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| Epitope Name | KF11 | |||||||||||||||||||||||
| Species (MHC/HLA) | human(B*57) | |||||||||||||||||||||||
Showing all: 7 variant(s).
| Variant ID. | 913 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KgFSPEVIPMF |
| Mutations | A/G |
| Epitope Location | A2G |
| HXB2 Location | A163G |
| Mutation Type | A: HLA association E: escape documented in this paper NSF: non-susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Mutation A163G is suggested to be a result of selection pressure from the HLA-B*57 allele, and can be transmitted and stable in the absence of HLA-B*57. Experimental evidence indicated that the mechanism of escape was an increased off-rate; CTL recognition of KgFSPEVIPMF was ablated. 3% of HLA-B*57-positive subjects, 2% of HLA-B*5801-positive subjects carried this variant. |
| Variant ID. | 3067 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KnFSPEVIPMF |
| Mutations | A/N |
| Epitope Location | A2N |
| HXB2 Location | A163N |
| Mutation Type | A: HLA association E: escape documented in this paper NSF: non-susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | Variant KnFSPEVIPMF (A163N) did not elicit response in EliSpot assays. 8% of HLA-B*57-positive subjects, 2% of HLA-B*5801-positive subjects, and 1% of HLA-B&57/5801-negative subjects carried this variant. |
| Variant ID. | 3068 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KgFnPEVIPMF |
| Mutations | A/G S/N |
| Epitope Location | A2G S4N |
| HXB2 Location | A163G S165N |
| Mutation Type | A: HLA association E: escape documented in this paper NSF: non-susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | For mutation A163G, S165N CTL recognition of KgFnPEVIPMF was ablated. 14% of HLA-B*57-positive subjects, 6% of HLA-B*5801-positive subjects, and 5% of HLA-B*57/5801-negative subjects carried this variant. |
| Variant ID. | 3069 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KgFkPEVIPMF |
| Mutations | A/G S/K |
| Epitope Location | A2G S4K |
| HXB2 Location | A163G S165K |
| Mutation Type | A: HLA association DHB: diminished HLA binding or increased off-rate E: escape documented in this paper NSF: non-susceptible form |
| Method | CD8 T-cell Elispot - IFNy, Sequence |
| Note | For mutation A163G, S165K CTL recognition of KgFkPEVIPMF was ablated. 8% of HLA-B*57-positive subjects carried this variant. |
| Variant ID. | 3070 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KsFSPEtIPMF |
| Mutations | A/S V/T |
| Epitope Location | A2S V7T |
| HXB2 Location | A163S V168T |
| Mutation Type | OV: observed variant |
| Method | Sequence |
| Note | Variant KsFSPEtIPMF (A163S, S168T) was found in 3% of HLA-B*57-positive subjects. |
| Variant ID. | 3071 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KAFSPEiIPMF |
| Mutations | V/I |
| Epitope Location | V7I |
| HXB2 Location | V168I |
| Mutation Type | OV: observed variant |
| Method | Sequence |
| Note | Variant KAFSPEiIPMF (V168I) was found in 4% of HLA-B*57-positive, and 7% of HLA-B*57/5802-negative subjects. |
| Variant ID. | 3072 |
|---|---|
| Epitope Seq. | KAFSPEVIPMF |
| Variant Seq. | KAFnPEVIPMF |
| Mutations | S/N |
| Epitope Location | S4N |
| HXB2 Location | S165N |
| Mutation Type | OV: observed variant |
| Method | Sequence |
| Note | Mutation S165N was found in 7% of HLA-B*57/5801-negative subjects. |
Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.