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Displaying record number 53776

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFSPEVIPMF   HLA association; escape documented in this paper; non-susceptible form
KnFSPEVIPMF   HLA association; escape documented in this paper; non-susceptible form
KgFnPEVIPMF   HLA association; escape documented in this paper; non-susceptible form
KgFkPEVIPMF   HLA association; diminished HLA binding or increased off-rate; escape documented in this paper; non-susceptible form
KsFSPEtIPMF   observed variant
KAFSPEiIPMF   observed variant
KAFnPEVIPMF   observed variant
Epitope Name KF11
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 7 variant(s).


Variant ID.  913
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type A: HLA association
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutation A163G is suggested to be a result of selection pressure from the HLA-B*57 allele, and can be transmitted and stable in the absence of HLA-B*57. Experimental evidence indicated that the mechanism of escape was an increased off-rate; CTL recognition of KgFSPEVIPMF was ablated. 3% of HLA-B*57-positive subjects, 2% of HLA-B*5801-positive subjects carried this variant.


Variant ID.  3067
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type A: HLA association
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant KnFSPEVIPMF (A163N) did not elicit response in EliSpot assays. 8% of HLA-B*57-positive subjects, 2% of HLA-B*5801-positive subjects, and 1% of HLA-B&57/5801-negative subjects carried this variant.


Variant ID.  3068
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type A: HLA association
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note For mutation A163G, S165N CTL recognition of KgFnPEVIPMF was ablated. 14% of HLA-B*57-positive subjects, 6% of HLA-B*5801-positive subjects, and 5% of HLA-B*57/5801-negative subjects carried this variant.


Variant ID.  3069
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFkPEVIPMF
Mutations A/G S/K
Epitope Location A2G S4K
HXB2 Location A163G S165K
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note For mutation A163G, S165K CTL recognition of KgFkPEVIPMF was ablated. 8% of HLA-B*57-positive subjects carried this variant.


Variant ID.  3070
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEtIPMF
Mutations A/S V/T
Epitope Location A2S V7T
HXB2 Location A163S V168T
Mutation Type OV: observed variant
Method Sequence
Note Variant KsFSPEtIPMF (A163S, S168T) was found in 3% of HLA-B*57-positive subjects.


Variant ID.  3071
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEiIPMF
Mutations V/I
Epitope Location V7I
HXB2 Location V168I
Mutation Type OV: observed variant
Method Sequence
Note Variant KAFSPEiIPMF (V168I) was found in 4% of HLA-B*57-positive, and 7% of HLA-B*57/5802-negative subjects.


Variant ID.  3072
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEVIPMF
Mutations S/N
Epitope Location S4N
HXB2 Location S165N
Mutation Type OV: observed variant
Method Sequence
Note Mutation S165N was found in 7% of HLA-B*57/5801-negative subjects.

References

Leslie2005a Alasdair Leslie, Daniel Kavanagh, Isobella Honeyborne, Katja Pfafferott, Charles Edwards, Tilly Pillay, Louise Hilton, Christina Thobakgale, Danni Ramduth, Rika Draenert, Sylvie Le Gall, Graz Luzzi, Anne Edwards, Christian Brander, Andrew K. Sewell, Sarah Moore, James Mullins, Corey Moore, Simon Mallal, Nina Bhardwaj, Karina Yusim, Rodney Phillips, Paul Klenerman, Bette Korber, Photini Kiepiela, Bruce Walker, and Philip Goulder. Transmission and Accumulation of CTL Escape Variants Drive Negative Associations between HIV Polymorphisms and HLA. J. Exp. Med., 201(6):891-902, 21 Mar 2005. PubMed ID: 15781581. Show all entries for this paper.


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