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Found 1 matching record:

Displaying record number 53748

HXB2 Location  Gag(20-29)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKKY   Epitope Alignment
Variants
RLRPGGrKKY   susceptible form
Epitope Name RY10
Species (MHC/HLA human(B62)

Variant Details

Showing all: 1 variant(s).


Variant ID.  752
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGrKKY
Mutations K/R
Epitope Location K7R
HXB2 Location K26R
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant was detected over a 5 year time period in a patient. The variant was better recognized than the wt epitope by patient CTLs.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


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