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Displaying record number 53745

HXB2 Location  Gag(167-175)   Gag Epitope Map
View variants at this location
Epitope EVIPMFSAL   Epitope Alignment
Variants
EVIPMFaAL   escape documented in this paper; TCR related mutation
EVIPMFtAL   escape documented in this paper; TCR related mutation
kVIPMFSAL   diminished HLA binding or increased off-rate
EiIPMFSAL   observed variant
EVIPvFSAL   observed variant
gVIPMFSAL   observed variant
EgIPMFSAL   observed variant
EVIPMFpAL   observed variant
EiIPMFaAL   observed variant
EmIPMFaAL   observed variant
EVIPMFttL   observed variant
EiIPMFtAL   observed variant
EeIPMFtAL   observed variant
EVIPiFtAL   observed variant
EVIPvFtAL   observed variant
EiIPiFtAL   observed variant
Species (MHC/HLA human(A*26:01, A*26:03)

Variant Details

Showing all: 16 variant(s).


Variant ID.  683
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFaAL
Mutations S/A
Epitope Location S7A
HXB2 Location S173A
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with equal affinity as the consensus form but could not be recognized by an EVIPMFSAL-specific T-cell clone, so it may mediate TCR escape


Variant ID.  684
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFtAL
Mutations S/T
Epitope Location S7T
HXB2 Location S173T
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Epitope Subtype A, B, CRF01_AE, D
Variant Subtype C
Method CD8 T-cell Elispot - IFNy
Note Variant bound to A*2603 with equal affinity as the consensus form but could not be recognized by an EVIPMFSAL-specific T-cell clone, so it may mediate TCR escape


Variant ID.  685
Epitope Seq.  EVIPMFSAL
Variant Seq.  kVIPMFSAL
Mutations E/K
Epitope Location E1K
HXB2 Location E167K
Mutation Type DHB: diminished HLA binding or increased off-rate
Method CD8 T-cell Elispot - IFNy
Note Variant did not bind to A*2603.


Variant ID.  686
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPMFSAL
Mutations V/I
Epitope Location V2I
HXB2 Location V168I
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.


Variant ID.  687
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPvFSAL
Mutations M/V
Epitope Location M5V
HXB2 Location M171V
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.


Variant ID.  688
Epitope Seq.  EVIPMFSAL
Variant Seq.  gVIPMFSAL
Mutations E/G
Epitope Location E1G
HXB2 Location E167G
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.


Variant ID.  689
Epitope Seq.  EVIPMFSAL
Variant Seq.  EgIPMFSAL
Mutations V/G
Epitope Location V2G
HXB2 Location V168G
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.


Variant ID.  690
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFpAL
Mutations S/P
Epitope Location S7P
HXB2 Location S173P
Mutation Type OV: observed variant
Variant Subtype CRF01_AE
Note Variant found in clade E from HIV sequence database.


Variant ID.  691
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPMFaAL
Mutations V/I S/A
Epitope Location V2I S7A
HXB2 Location V168I S173A
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.


Variant ID.  692
Epitope Seq.  EVIPMFSAL
Variant Seq.  EmIPMFaAL
Mutations V/M S/A
Epitope Location V2M S7A
HXB2 Location V168M S173A
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.


Variant ID.  693
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPMFttL
Mutations S/T A/T
Epitope Location S7T A8T
HXB2 Location S173T A174T
Mutation Type OV: observed variant
Variant Subtype B
Note Variant found in clade B from HIV sequence database.


Variant ID.  694
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPMFtAL
Mutations V/I S/T
Epitope Location V2I S7T
HXB2 Location V168I S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.


Variant ID.  695
Epitope Seq.  EVIPMFSAL
Variant Seq.  EeIPMFtAL
Mutations V/E S/T
Epitope Location V2E S7T
HXB2 Location V168E S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.


Variant ID.  696
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPiFtAL
Mutations M/I S/T
Epitope Location M5I S7T
HXB2 Location M171I S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.


Variant ID.  697
Epitope Seq.  EVIPMFSAL
Variant Seq.  EVIPvFtAL
Mutations M/V S/T
Epitope Location M5V S7T
HXB2 Location M171V S173T
Mutation Type OV: observed variant
Variant Subtype A
Note Variant found in clade A from HIV sequence database.


Variant ID.  698
Epitope Seq.  EVIPMFSAL
Variant Seq.  EiIPiFtAL
Mutations V/I M/I S/T
Epitope Location V2I M5I S7T
HXB2 Location V168I M171I S173T
Mutation Type OV: observed variant
Variant Subtype C
Note Variant found in clade C from HIV sequence database.

References

Kawashima2005 Yuka Kawashima, Manami Satoh, Shinichi Oka, and Masafumi Takiguchi. Identification and Characterization of HIV-1 Epitopes Presented by HLA-A*2603: Comparison Between HIV-1 Epitopes Presented by A*2601 and A*2603. Hum. Immunol., 66(11):1155-1166, Nov 2005. PubMed ID: 16571416. Show all entries for this paper.


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