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Found 1 matching record:

Displaying record number 53633

HXB2 Location Gag(20-28) Gag Epitope Map
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RLRPGGKKK

`RLRPGGKKq`		diminished response; susceptible form
`RLRPGGKKr`		susceptible form

Species (MHC/HLA) human(A3, A30, B42, B62)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`114`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKq`
Mutations	K/Q
Epitope Location	K9Q
HXB2 Location	K28Q
Mutation Type	DR: diminished response SF: susceptible form
Method	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note	The majority of viral sequences prior to therapy were rlrpggkkQ. At week 14 of therapy a major change in the viral quasispecies occurred: the variants present were found to be rlrpggkkK (14/16 clones) and rlrpggkkR (2/16 clones), both well recognized by HIV-specific CD8 T cells. At week 19, the quasispecies reverted back to the less well-recognized rlrpggkkQ variant.

Variant ID.	`115`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K28R
Mutation Type	SF: susceptible form
Method	Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note	The majority of viral sequences prior to therapy were rlrpggkkQ. At week 14 of therapy a major change in the viral quasispecies occurred: the variants present were found to be rlrpggkkK (14/16 clones) and rlrpggkkR (2/16 clones), both well recognized by HIV-specific CD8 T cells. At week 19, the quasispecies reverted back to the less well-recognized rlrpggkkQ variant.

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.