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Found 1 matching record:

Displaying record number 53629

HXB2 Location  Gag(19-27)   Gag Epitope Map
View variants at this location
Epitope IRLRPGGKK   Epitope Alignment
Variants
IRLRPGGrK   susceptible form
Species (MHC/HLA human(B27)

Variant Details

Showing all: 1 variant(s).


Variant ID.  113
Epitope Seq.  IRLRPGGKK
Variant Seq.  IRLRPGGrK
Mutations K/R
Epitope Location K8R
HXB2 Location K26R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay, Intracellular cytokine staining
Note The dominant viral sequence was irlrpggRk, found in 12/15 clones, while the screening sequence IRLRPGGKK was found in 3/15 clones. The least frequent variant stimulated the strongest response.

References

Casazza2005a Joseph P. Casazza, Michael R. Betts, Brenna J. Hill, Jason M. Brenchley, David A. Price, Daniel C. Douek, and Richard A. Koup. Immunologic Pressure within Class I-Restricted Cognate Human Immunodeficiency Virus Epitopes during Highly Active Antiretroviral Therapy. J. Virol., 79(6):3653-3663, Mar 2005. PubMed ID: 15731259. Show all entries for this paper.


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