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Found 1 matching record:

Displaying record number 53414

HXB2 Location  Gag(213-232)   Gag Epitope Map
View variants at this location
Epitope DRLHPVHAGPAAPGQMREPR   Epitope Alignment
Variants
DRLHPVHAGPiAPGQMREPR   diminished response
Epitope Name DRL
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  1353
Epitope Seq.  DRLHPVHAGPAAPGQMREPR
Variant Seq.  DRLHPVHAGPiAPGQMREPR
Mutations A/I
Epitope Location A11I
HXB2 Location A223I
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Sequence, Tetramer binding
Note Diminished response at higher peptide concentration, similar response at lower peptide concentration.

References

Oxenius2004 Annette Oxenius, David A. Price, Alexandra Trkola, Charles Edwards, Emma Gostick, Hua-Tang Zhang, Philippa J. Easterbrook, Tin Tun, Andrew Johnson, Anele Waters, Edward C. Holmes, and Rodney E. Phillips. Loss of Viral Control in Early HIV-1 Infection Is Temporally Associated with Sequential Escape from CD8+ T Cell Responses and Decrease in HIV-1-Specific CD4+ and CD8+ T Cell Frequencies. J. Infect. Dis., 190(4):713-721, 15 Aug 2004. PubMed ID: 15272399. Show all entries for this paper.


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