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Displaying record number 53386

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVcvi   diminished response; escape documented in this paper; subtype-specific non-susceptible form; TCR related mutation
SLfNTVATL   diminished response; escape documented in this paper; subtype-specific non-susceptible form; TCR related mutation
SLfNaVATL   diminished response; escape documented in this paper; subtype-specific non-susceptible form; TCR related mutation
SLaNTVATL   diminished response; escape documented in this paper; TCR related mutation
SLYaTVATL   diminished response; escape documented in this paper; TCR related mutation
SLYNaVATL   diminished response; escape documented in this paper; TCR related mutation
SLYNTaATL   susceptible form
SLYNTVAaL   diminished response; escape documented in this paper; TCR related mutation
Epitope Name gag 77-85
Species (MHC/HLA human(A2)

Variant Details

Showing all: 8 variant(s).


Variant ID.  1004
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVcvi
Mutations Y/F A/C T/V L/I
Epitope Location Y3F A7C T8V L9I
HXB2 Location Y79F A83C T84V L85I
Mutation Type DR: diminished response
E: escape documented in this paper
SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
Epitope Subtype B
Variant Subtype HIV-2
Method CD8 T-cell Elispot - IFNy
Note Naturally-occurring HIV-2 variant. It was not recognized well by CTLs from four A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.


Variant ID.  1005
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type DR: diminished response
E: escape documented in this paper
SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
Epitope Subtype B
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note Naturally-occurring clade A variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.


Variant ID.  1006
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNaVATL
Mutations Y/F T/A
Epitope Location Y3F T5A
HXB2 Location Y79F T81A
Mutation Type DR: diminished response
E: escape documented in this paper
SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
Epitope Subtype B
Variant Subtype G
Method CD8 T-cell Elispot - IFNy
Note Naturally-occurring clade G variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.


Variant ID.  1007
Epitope Seq.  SLYNTVATL
Variant Seq.  SLaNTVATL
Mutations Y/A
Epitope Location Y3A
HXB2 Location Y79A
Mutation Type DR: diminished response
E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Artificially synthesized variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.


Variant ID.  1008
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYaTVATL
Mutations N/A
Epitope Location N4A
HXB2 Location N80A
Mutation Type DR: diminished response
E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Artificially synthesized variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.


Variant ID.  1009
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNaVATL
Mutations T/A
Epitope Location T5A
HXB2 Location T81A
Mutation Type DR: diminished response
E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Artificially synthesized variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.


Variant ID.  1010
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTaATL
Mutations V/A
Epitope Location V6A
HXB2 Location V82A
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note The only artificially synthesized variant that did not abrogate recognition by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with slightly reduced affinity than the wt epitope.


Variant ID.  1011
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAaL
Mutations T/A
Epitope Location T8A
HXB2 Location T84A
Mutation Type DR: diminished response
E: escape documented in this paper
TCR: TCR related mutation
Method CD8 T-cell Elispot - IFNy
Note Artificially synthesized variant. It was poorly recognized by CTLs from some of the A2+ HIV infected asymptomatic individuals. The variant bound to HLA-A2 with higher affinity than the wt epitope, indicating that the poor CTL recognition was due to inhibition of TCR recognition.

References

Lopes2003 A. Ross Lopes, Assan Jaye, Lucy Dorrell, Sehu Sabally, Abraham Alabi, Nicola A. Jones, Darren R. Flower, Anne De Groot, Phillipa Newton, R. Monica Lascar, Ian Williams, Hilton Whittle, Antonio Bertoletti, Persephone Borrow, and Mala K. Maini. Greater CD8+ TCR Heterogeneity and Functional Flexibility in HIV-2 Compared to HIV-1 Infection. J. Immunol., 171(1):307-316, 1 Jul 2003. PubMed ID: 12817012. Show all entries for this paper.


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