HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 53201

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
KIRLRPGGq   escape documented in this paper; processing
Epitope Name KK9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.  31
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGq
Mutations K/Q
Epitope Location K9Q
HXB2 Location K26Q
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay
Note Variant inhibits processing, resulting in rapid decline in the KK9 specific CD8+ T-cell response.


Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.

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