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Displaying record number 53157

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiATL   escape documented in this paper; processing; susceptible form
SvYNTVATL   escape documented in this paper; processing; susceptible form
SLYNlVATL   escape documented in this paper; processing; susceptible form
SLfNTVAvL   escape documented in this paper; processing; susceptible form
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1878
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type E: escape documented in this paper
P: processing
SF: susceptible form
Method Chromium-release assay
Note Index epitope SL9 and this variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as endogenously expressed sequences on transformed cells, but were recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed.


Variant ID.  1881
Epitope Seq.  SLYNTVATL
Variant Seq.  SvYNTVATL
Mutations L/V
Epitope Location L2V
HXB2 Location L78V
Mutation Type E: escape documented in this paper
P: processing
SF: susceptible form
Method Chromium-release assay
Note This variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed.


Variant ID.  1882
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNlVATL
Mutations T/L
Epitope Location T5L
HXB2 Location T81L
Mutation Type E: escape documented in this paper
P: processing
SF: susceptible form
Method Chromium-release assay
Note This variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed.


Variant ID.  1883
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type E: escape documented in this paper
P: processing
SF: susceptible form
Method Chromium-release assay
Note This variant escaped from killing by Gag-epitope-specific CTL clonal lines when presented as an endogenously expressed sequence on transformed cells, but was recognized when exogenously loaded as synthetic peptide. A processing or epitope presentation mutation is assumed.

References

Yokomaku2004 Yoshiyuki Yokomaku, Hideka Miura, Hiroko Tomiyama, Ai Kawana-Tachikawa, Masafumi Takiguchi, Asato Kojima, Yoshiyuki Nagai, Aikichi Iwamoto, Zene Matsuda, and Koya Ariyoshi. Impaired Processing and Presentation of Cytotoxic-T-Lymphocyte (CTL) Epitopes Are Major Escape Mechanisms from CTL Immune Pressure in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(3):1324-1332, Feb 2004. PubMed ID: 14722287. Show all entries for this paper.


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