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Displaying record number 52994

HXB2 Location Gag(20-28) Gag Epitope Map
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Epitope

RLRPGGKKK

Epitope Alignment

Variants

RLRPGGKKr susceptible form

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`305`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K28R
Mutation Type	SF: susceptible form
Note	The variant became fixed in the viral population at 20 months post-seroconversion. CTL responses to both wild type and variant peptides were detectable and decreased over time, then increased after mutation fixation.

References

Geels2003 Mark J. Geels, Marion Cornelissen, Hanneke Schuitemaker, Kiersten Anderson, David Kwa, Jolanda Maas, John T. Dekker, Elly Baan, Fokla Zorgdrager, Remco van den Burg, Martijn van Beelen, Vladimir V. Lukashov, Tong-Ming Fu, William A. Paxton, Lia van der Hoek, Sheri A. Dubey, John W. Shiver, and Jaap Goudsmit. Identification of Sequential Viral Escape Mutants Associated with Altered T-Cell Responses in a Human Immunodeficiency Virus Type 1-Infected Individual. J. Virol., 77(23):12430-12440, Dec 2003. PubMed ID: 14610167. Show all entries for this paper.