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Found 1 matching record:

Displaying record number 52824

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKt   diminished response
Epitope Name A3-RK9 Ga9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  43
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKt
Mutations K/T
Epitope Location K9T
HXB2 Location K28T
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant rlrpggkkT. The CTL response declined over time, and the response to the second variant was lower than to the first one

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


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