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Displaying record number 52791

HXB2 Location Gag(77-85) Gag Epitope Map
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SLYNTVATL

`SLfNTVATL`		escape documented in this paper; susceptible form; TCR related mutation
`SLYNTiATL`		escape documented in this paper
`SLYNTiAvL`		escape documented in this paper; non-susceptible form; susceptible form; TCR related mutation
`SLfNTiATL`		escape documented in this paper; non-susceptible form; susceptible form; TCR related mutation
`SLYNlVAvL`		escape documented in this paper; non-susceptible form; TCR related mutation
`SLYNTVAaL`		observed variant

Epitope Name SL9

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 6 variant(s).

Variant ID.	`1856`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTVATL`
Mutations	Y/F
Epitope Location	Y3F
HXB2 Location	Y79F
Mutation Type	E: escape documented in this paper SF: susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clone 161JxA14 recognizes this variant but Clone 18030D23 from a different subject does not. Both clones recognize SL9 index sequence similarly.

Variant ID.	`1857`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiATL`
Mutations	V/I
Epitope Location	V6I
HXB2 Location	V82I
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay, Sequence
Note	After 2 weeks of selective pressure by culturing with 1 of 4 SL9-specific clones i.e. 161JxA14, this variant arose and was not recognized.

Variant ID.	`1858`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTiAvL`
Mutations	V/I T/V
Epitope Location	V6I T8V
HXB2 Location	V82I T84V
Mutation Type	E: escape documented in this paper NSF: non-susceptible form SF: susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 Clade B index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.

Variant ID.	`1859`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLfNTiATL`
Mutations	Y/F V/I
Epitope Location	Y3F V6I
HXB2 Location	Y79F V82I
Mutation Type	E: escape documented in this paper NSF: non-susceptible form SF: susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clone 18030D23 recognizes this variant but Clone 161JxA14 from a different subject does not. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.

Variant ID.	`1860`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNlVAvL`
Mutations	T/L T/V
Epitope Location	T5L T8V
HXB2 Location	T81L T84V
Mutation Type	E: escape documented in this paper NSF: non-susceptible form TCR: TCR related mutation
Method	Chromium-release assay, Relative replication capacity assay, Sequence
Note	CTL Clones 18030D23 and 161JxA14 from different subjects do not recognize this variant. Both clones recognize SL9 index sequence similarly. Since the clones are from different HIV-1 infected subjects, with different TCR sequences, TCR is seen to contribute to escape differentially in this instance.

Variant ID.	`1861`
Epitope Seq.	`SLYNTVATL`
Variant Seq.	`SLYNTVAaL`
Mutations	T/A
Epitope Location	T8A
HXB2 Location	T84A
Mutation Type	OV: observed variant
Method	Chromium-release assay, Sequence
Note	This minority epitope variant was seen after 2 weeks of selection by SL9-specific clone 18030D23.

References

Yang2003 Otto O Yang, Phuong Thi Nguyen Sarkis, Ayub Ali, Jason D Harlow, Christian Brander, Spyros A Kalams, and Bruce D Walker. Determinant of HIV-1 Mutational Escape from Cytotoxic T Lymphocytes. J. Exp. Med., 197(10):1365-1375, May 2003. PubMed ID: 12743169. Show all entries for this paper.