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Displaying record number 49

HXB2 Location  Gag(24-35)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKLKHIV   Epitope Alignment
Variants
GGKKKYKLKHIi   susceptible form
GrKKKYKLKHIV   escape documented in this paper
GrKKKYKfKHIV   escape documented in this paper
rGKKrYKLKHIV   observed variant
GGKKqYrLKHIV   observed variant
GGKKKYqLKHIV   observed variant
GGKKKYaLKHli   observed variant
Species (MHC/HLA human(B8)

Variant Details

Showing all: 7 variant(s).


Variant ID.  373
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GGKKKYKLKHIi
Mutations V/I
Epitope Location V12I
HXB2 Location V35I
Mutation Type SF: susceptible form
Note This variant was recognized as efficiently as the wt epitope by patient CTLs.


Variant ID.  374
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GrKKKYKLKHIV
Mutations G/R
Epitope Location G2R
HXB2 Location G25R
Mutation Type E: escape documented in this paper
Note This variant failed to be recognized by CTLs and failed to induce target specific lysis.


Variant ID.  375
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GrKKKYKfKHIV
Mutations G/R L/F
Epitope Location G2R L8F
HXB2 Location G25R L31F
Mutation Type E: escape documented in this paper
Note This variant failed to be recognized by CTLs and failed to induce target specific lysis.


Variant ID.  376
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  rGKKrYKLKHIV
Mutations G/R K/R
Epitope Location G1R K5R
HXB2 Location G24R K28R
Mutation Type OV: observed variant
Note Previously published variants of this epitope.


Variant ID.  377
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GGKKqYrLKHIV
Mutations K/Q K/R
Epitope Location K5Q K7R
HXB2 Location K28Q K30R
Mutation Type OV: observed variant
Note Previously published variants of this epitope.


Variant ID.  378
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GGKKKYqLKHIV
Mutations K/Q
Epitope Location K7Q
HXB2 Location K30Q
Mutation Type OV: observed variant
Note Previously published variants of this epitope.


Variant ID.  379
Epitope Seq.  GGKKKYKLKHIV
Variant Seq.  GGKKKYaLKHli
Mutations I/L V/I K/A
Epitope Location I11L V12I K7A
HXB2 Location I34L V35I K30A
Mutation Type OV: observed variant
Note Previously published variants of this epitope.

References

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.

Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.


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