HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(24-35) | Gag Epitope Map
View variants at this location |
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| Epitope |
GGKKKYKLKHIV
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Epitope Alignment | ||||||||||||||||||||||
| Variants |
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| Species (MHC/HLA) | human(B8) | |||||||||||||||||||||||
Showing all: 7 variant(s).
| Variant ID. | 373 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | GGKKKYKLKHIi |
| Mutations | V/I |
| Epitope Location | V12I |
| HXB2 Location | V35I |
| Mutation Type | SF: susceptible form |
| Note | This variant was recognized as efficiently as the wt epitope by patient CTLs. |
| Variant ID. | 374 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | GrKKKYKLKHIV |
| Mutations | G/R |
| Epitope Location | G2R |
| HXB2 Location | G25R |
| Mutation Type | E: escape documented in this paper |
| Note | This variant failed to be recognized by CTLs and failed to induce target specific lysis. |
| Variant ID. | 375 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | GrKKKYKfKHIV |
| Mutations | G/R L/F |
| Epitope Location | G2R L8F |
| HXB2 Location | G25R L31F |
| Mutation Type | E: escape documented in this paper |
| Note | This variant failed to be recognized by CTLs and failed to induce target specific lysis. |
| Variant ID. | 376 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | rGKKrYKLKHIV |
| Mutations | G/R K/R |
| Epitope Location | G1R K5R |
| HXB2 Location | G24R K28R |
| Mutation Type | OV: observed variant |
| Note | Previously published variants of this epitope. |
| Variant ID. | 377 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | GGKKqYrLKHIV |
| Mutations | K/Q K/R |
| Epitope Location | K5Q K7R |
| HXB2 Location | K28Q K30R |
| Mutation Type | OV: observed variant |
| Note | Previously published variants of this epitope. |
| Variant ID. | 378 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | GGKKKYqLKHIV |
| Mutations | K/Q |
| Epitope Location | K7Q |
| HXB2 Location | K30Q |
| Mutation Type | OV: observed variant |
| Note | Previously published variants of this epitope. |
| Variant ID. | 379 |
|---|---|
| Epitope Seq. | GGKKKYKLKHIV |
| Variant Seq. | GGKKKYaLKHli |
| Mutations | I/L V/I K/A |
| Epitope Location | I11L V12I K7A |
| HXB2 Location | I34L V35I K30A |
| Mutation Type | OV: observed variant |
| Note | Previously published variants of this epitope. |
Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.
Phillips1991 R. E. Phillips, S. Rowland-Jones, D. F. Nixon, F. M. Gotch, J. P. Edwards, A. O. Ogunlesi, J. G. Elvin, J. A. Rothbard, C. R. Bangham, C. R. Rizza, and A. J. McMichael. Human Immunodeficiency Virus Genetic Variation That Can Escape Cytotoxic T Cell Recognition. Nature, 354:453-459, 1991. Fluctuations in the specificity of cytotoxic T-cells for HIV were correlated with variability in proviral gag (DNA) epitope sequences. PubMed ID: 1721107. Show all entries for this paper.