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Found 1 matching record:

Displaying record number 40

HXB2 Location  Gag(24-31)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKL   Epitope Alignment
Variants
GGKKqYKL   escape documented in this paper
erKKqYKL   observed variant
Species (MHC/HLA human(B8)

Variant Details

Showing all: 2 variant(s).


Variant ID.  1440
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKqYKL
Mutations K/Q
Epitope Location K5Q
HXB2 Location K28Q
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay, HLA binding
Note This variant from the index was seen from the earliest recorded time point. It is either an escape that became fixed or infection occurred with the virus bearing variant Q5. Diminished recognition by index epitope-specific CTL was measured.


Variant ID.  1441
Epitope Seq.  GGKKKYKL
Variant Seq.  erKKqYKL
Mutations G/E G/R K/Q
Epitope Location G1E G2R K5Q
HXB2 Location G24E G25R K28Q
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Note This variant from the index epitope was seen at the earliest recorded time point but was later lost.

References

Price1997 D. A. Price, P. J. Goulder, P. Klenerman, A. K. Sewell, P. J. Easterbrook, M. Troop, C. R. Bangham, and R. E. Phillips. Positive Selection of HIV-1 Cytotoxic T Lymphocyte Escape Variants during Primary Infection. Proc. Natl. Acad. Sci. U.S.A., 94:1890-1895, 1997. Cytotoxic T lymphocytes (CTLs) are thought to play a crucial role in the termination of the acute primary HIV-1 syndrome, but clear evidence for this presumption has been lacking. Here we demonstrate positive selection of HIV-1 proviral sequences encoding variants within a CTL epitope in Nef, a gene product critical for viral pathogenicity, during and after seroconversion. These positively selected HIV-1 variants carried epitope sequence changes that either diminished or escaped CTL recognition. Other proviruses had mutations that abolished the Nef epitope altogether. These results provide clear evidence that CTLs exert selection pressure on the viral population in acute HIV-1 infection. PubMed ID: 9050875. Show all entries for this paper.


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