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Displaying record number 214

HXB2 Location  Gag(215-224)   Gag Epitope Map
View variants at this location
Epitope VHPVHAGPIA   Epitope Alignment
Variants
lHPVHAGPvA   susceptible form
lHPVHAGPIA   susceptible form
lHPVHAGPIt   susceptible form
lHPaqAGPIA   susceptible form
Species (MHC/HLA human(B55)

Variant Details

Showing all: 4 variant(s).


Variant ID.  1624
Epitope Seq.  VHPVHAGPIA
Variant Seq.  lHPVHAGPvA
Mutations V/L I/V
Epitope Location V1L I9V
HXB2 Location V215L I223V
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay
Note This naturally occurring, strain PH136 variant, was recognized by a Patient LWR CTL clone.


Variant ID.  1625
Epitope Seq.  VHPVHAGPIA
Variant Seq.  lHPVHAGPIA
Mutations V/L
Epitope Location V1L
HXB2 Location V215L
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay
Note This naturally occurring, strain RF variant, was recognized by a Patient LWR CTL clone.


Variant ID.  1626
Epitope Seq.  VHPVHAGPIA
Variant Seq.  lHPVHAGPIt
Mutations V/L A/T
Epitope Location V1L A10T
HXB2 Location V215L A224T
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay
Note This naturally occurring, strain MN variant, was recognized by a Patient LWR CTL clone.


Variant ID.  1627
Epitope Seq.  VHPVHAGPIA
Variant Seq.  lHPaqAGPIA
Mutations V/L V/A H/Q
Epitope Location V1L V4A H5Q
HXB2 Location V215L V218A H219Q
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method Chromium-release assay
Note This naturally occurring, strain JH3 variant, was very poorly recognized by a Patient LWR CTL clone.

References

Sipsas1997 N. V. Sipsas, S. A. Kalams, A. Trocha, S. He, W. A. Blattner, B. D. Walker, and R. P. Johnson. Identification of Type-Specific Cytotoxic T Lymphocyte Responses to Homologous Viral Proteins in Laboratory Workers Accidentally Infected with HIV-1. J. Clin. Invest., 99:752-762, 1997. To examine a situation where the autologous strain and the reference reagents would be the same, the CTL response of three lab workers accidentally infected with HIV IIIB was studied. Both group specific and type specific epitopes were targets for CTL clones. One subject had a broadening of CTL response over time, using a broad range of restricting HLA class I alleles. Characterization of the cytotoxic T lymphocyte (CTL) response against HIV-1 has been limited by the use of target cells expressing viral proteins from laboratory isolates of HIV-1. This approach has favored identification of group-specific CTL responses and precluded assessment of the extent of type-specific CTL responses directed against HIV-1. Using cells expressing viral proteins from the HIV-1 IIIB strain, we performed a detailed characterization of HIV-1-specific CTL response in three laboratory workers accidentally infected with HIV-1 IIIB. Eight of the epitopes identified were group specific, lying in relatively conserved regions of Gag, reverse transcriptase, and envelope. Three type-specific epitopes were identified, two of them in highly variable regions of envelope. In longitudinal studies in one subject, seven different epitopes and five different restricting HLA class I alleles were identified, with a progressive increase in the number of CTL epitopes recognized by this subject over time. Our data demonstrate that type-specific CTL responses make up a significant proportion of the host cellular immune response against HIV-1 and that a broadening of epitope specificity may occur. PubMed ID: 9045880. Show all entries for this paper.


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