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Displaying record number 195

HXB2 Location  Gag(183-191)   Gag Epitope Map
View variants at this location
Epitope DLNTMLNTV   Epitope Alignment
Variants
DLNmMLNiV   observed variant
Species (MHC/HLA human(B14, Cw8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  1556
Epitope Seq.  DLNTMLNTV
Variant Seq.  DLNmMLNiV
Mutations T/M T/I
Epitope Location T4M T8I
HXB2 Location T186M T190I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype D
Method Chromium-release assay
Note 5/6 Kenyan HEPS subjects recognized this clade B epitope which differed from the clade D variant, DLNmMLNiV.

References

RowlandJones1998b S. Rowland-Jones, T. Dong, P. Krausa, J. Sutton, H. Newell, K. Ariyoshi, F. Gotch, S. Sabally, T. Corrah, J. Kimani, K. MacDonald, F. Plummer, J. Ndinya-Achola, H. Whittle, and A. McMichael. The Role of Cytotoxic T Cells in HIV Infection. Dev. Biol. Stand., 92:209-214, 1998. In this paper CTL response to previously defined conserved epitopes was found in exposed but uninfected prostitutes in Nairobi. Subtypes A and D are circulating in this regions, and the reactive epitopes tended to be conserved. Similarly previous studies in the Gambia showed that exposed but uninfected prostitutes tended to have B35 presented CTL epitopes conserved between HIV-1 and HIV-2. It was suggested that what was special about B35 is simply that it presents epitopes found both in HIV-1 and HIV-2. PubMed ID: 9554277. Show all entries for this paper.


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