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Displaying record number 1819

HXB2 Location Gag(19-27) Gag Epitope Map
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IRLRPGGKK

`IRLRPGrKK`		observed variant
`IRLRPrrKK`		observed variant
`IRkRPGGKK`		observed variant
`IRLgPGGsK`		inferred escape
`IRLRPGGsK`		inferred escape

Epitope Name IK9

Species (MHC/HLA) human(B27)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`385`
Epitope Seq.	`IRLRPGGKK`
Variant Seq.	`IRLRPGrKK`
Mutations	G/R
Epitope Location	G7R
HXB2 Location	G25R
Mutation Type	OV: observed variant
Note	Variant found in one B27 positive child in 4/11 clones, but not in its B27 positive mother

Variant ID.	`386`
Epitope Seq.	`IRLRPGGKK`
Variant Seq.	`IRLRPrrKK`
Mutations	G/R G/R
Epitope Location	G6R G7R
HXB2 Location	G24R G25R
Mutation Type	OV: observed variant
Note	Variant found in one B27 positive child in 1/11 clones, but not in its B27 positive mother

Variant ID.	`387`
Epitope Seq.	`IRLRPGGKK`
Variant Seq.	`IRkRPGGKK`
Mutations	L/K
Epitope Location	L3K
HXB2 Location	L21K
Mutation Type	OV: observed variant
Note	Variant found in one B27 positive child in 1/19 clones, but not in its B27 positive mother

Variant ID.	`388`
Epitope Seq.	`IRLRPGGKK`
Variant Seq.	`IRLgPGGsK`
Mutations	R/G K/S
Epitope Location	R4G K8S
HXB2 Location	R22G K26S
Mutation Type	IE: inferred escape
Note	Author tabulates this variant found in one B27 positive child in 1/8 clones, and in its B27 positive mother in 1/10 clones as an escape variant.

Variant ID.	`389`
Epitope Seq.	`IRLRPGGKK`
Variant Seq.	`IRLRPGGsK`
Mutations	K/S
Epitope Location	K8S
HXB2 Location	K26S
Mutation Type	IE: inferred escape
Note	Variant found in one B27 positive child in 7/8 clones, and in its B27 positive mother in 9/10 clones.

References

Goulder2001c P. J. Goulder, C. Brander, Y. Tang, C. Tremblay, R. A. Colbert, M. M. Addo, E. S. Rosenberg, T. Nguyen, R. Allen, A. Trocha, M. Altfeld, S. He, M. Bunce, R. Funkhouser, S. I. Pelton, S. K. Burchett, K. McIntosh, B. T. Korber, and B. D. Walker. Evolution and transmission of stable CTL escape mutations in HIV infection. Nature, 412(6844):334-8, 19 Jul 2001. PubMed ID: 11460164. Show all entries for this paper.