HIV molecular immunology database
Found 1 matching record:
| HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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| Epitope |
TPQDLNMML
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(B53) | |||||
Showing all: 1 variant(s).
| Variant ID. | 176 |
|---|---|
| Epitope Seq. | TPQDLNMML |
| Variant Seq. | TPQDLNtML |
| Mutations | M/T |
| Epitope Location | M7T |
| HXB2 Location | M186T |
| Mutation Type | SNSF: subtype-specific non-susceptible form TCR: TCR related mutation |
| Epitope Subtype | A |
| Variant Subtype | B, C, D |
| Method | CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding |
| Note | TPQDLNMML was subtype A-specific with no cross-recognition of the subtype B, C, and D variant, TPQDLNTML, although the B/C/D variant bound more efficiently to B53 in vitro. Position 7 shows great positional variation in crystal structures of two HLA-B53 complexes, suggesting that variation here might significantly alter the position of the peptide in the binding groove and thus affect TCR interactions. |
Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.