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Displaying record number 1649

HXB2 Location Gag(77-85) Gag Epitope Map
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Epitope

SLFNTVATL

Epitope Alignment

Variants

SLyNTVATL susceptible form

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`670`
Epitope Seq.	`SLFNTVATL`
Variant Seq.	`SLyNTVATL`
Mutations	F/Y
Epitope Location	F3Y
HXB2 Location	F79Y
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	This epitope and the variant were recognized by 22/26 HLA-A2+ infected women but only by 1/10 HIV-exposed, persistently seronegative women (HEPS). Responses to the epitope and the variant were much higher after HIV-1 seroconversion in previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.