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Found 1 matching record:

Displaying record number 1649

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
Variants
SLyNTVATL   susceptible form
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  670
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNTVATL
Mutations F/Y
Epitope Location F3Y
HXB2 Location F79Y
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 22/26 HLA-A2+ infected women but only by 1/10 HIV-exposed, persistently seronegative women (HEPS). Responses to the epitope and the variant were much higher after HIV-1 seroconversion in previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


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