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Displaying record number 107

HXB2 Location Gag(84-91) Gag Epitope Map
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TLYCVHQR

`TLYCVHQk`		susceptible form
`TLYCVHQq`		diminished response
`TLYCVHeR`		escape documented in this paper

Species (MHC/HLA) human(A11)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`412`
Epitope Seq.	`TLYCVHQR`
Variant Seq.	`TLYCVHQk`
Mutations	R/K
Epitope Location	R8K
HXB2 Location	R91K
Mutation Type	SF: susceptible form
Method	Chromium-release assay
Note	Variant found in patient. It was recognized by patient CTLs and induced target specific lysis.

Variant ID.	`413`
Epitope Seq.	`TLYCVHQR`
Variant Seq.	`TLYCVHQq`
Mutations	R/Q
Epitope Location	R8Q
HXB2 Location	R91Q
Mutation Type	DR: diminished response
Method	Chromium-release assay
Note	Variant found in patient. It was recognized by patient CTLs but less than the R/K variant, and only induced target specific lysis at high concentrations. This mutation did not abrogate virus replication.

Variant ID.	`414`
Epitope Seq.	`TLYCVHQR`
Variant Seq.	`TLYCVHeR`
Mutations	Q/E
Epitope Location	Q7E
HXB2 Location	Q90E
Mutation Type	E: escape documented in this paper
Method	Chromium-release assay
Note	Variant found in patient. It was not able to induce target specific lysis. This mutation did not abrogate virus replication.

References

Harrer1998 T. Harrer, E. Harrer, P. Barbosa, F. Kaufmann, R. Wagner, S. Bruggemann, J. R. Kalden, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual. J. Immunol., 161:4875-4881, 1998. PubMed ID: 9794421. Show all entries for this paper.