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Found 1 matching record:

Displaying record number 107

HXB2 Location  Gag(84-91)   Gag Epitope Map
View variants at this location
Epitope TLYCVHQR   Epitope Alignment
Variants
TLYCVHQk   susceptible form
TLYCVHQq   diminished response
TLYCVHeR   escape documented in this paper
Species (MHC/HLA human(A11)

Variant Details

Showing all: 3 variant(s).


Variant ID.  412
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHQk
Mutations R/K
Epitope Location R8K
HXB2 Location R91K
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Variant found in patient. It was recognized by patient CTLs and induced target specific lysis.


Variant ID.  413
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHQq
Mutations R/Q
Epitope Location R8Q
HXB2 Location R91Q
Mutation Type DR: diminished response
Method Chromium-release assay
Note Variant found in patient. It was recognized by patient CTLs but less than the R/K variant, and only induced target specific lysis at high concentrations. This mutation did not abrogate virus replication.


Variant ID.  414
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHeR
Mutations Q/E
Epitope Location Q7E
HXB2 Location Q90E
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note Variant found in patient. It was not able to induce target specific lysis. This mutation did not abrogate virus replication.

References

Harrer1998 T. Harrer, E. Harrer, P. Barbosa, F. Kaufmann, R. Wagner, S. Bruggemann, J. R. Kalden, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual. J. Immunol., 161:4875-4881, 1998. PubMed ID: 9794421. Show all entries for this paper.


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