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Found 1 matching record:

Displaying record number 102

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
Variants
SLyNTVATL   subtype-specific non-susceptible form
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  171
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNTVATL
Mutations F/Y
Epitope Location F3Y
HXB2 Location F79Y
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype A, C
Variant Subtype B
Note CTL responses in three individuals with non-clade B infections were studied, 2 with subtype A infections, 1 with subtype C -- their infections all originated in East Africa. This epitope is most commonly SLYNTVATL in B subtype, and CTL from the C subtype infection did not recognize B clade gag or the 3Y form of the epitope, but did recognize the predominant A and C clade form, SLFNTVATL.

References

Dorrell1999 L. Dorrell, T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. Distinct Recognition of Non-Clade B Human Immunodeficiency Virus Type 1 Epitopes by Cytotoxic T Lymphocytes Generated from Donors Infected in Africa. J. Virol., 73:1708-1714, 1999. PubMed ID: 9882385. Show all entries for this paper.


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