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Displaying record number 986

HXB2 Location  Nef(73-82)   Nef Epitope Map
View variants at this location
Epitope QVPLRPMTYK   Epitope Alignment
Variants
QiPLRPMTYK   susceptible form
QVPLaPMTYK   diminished response
QVPLgPMTYK   diminished response
QVPLgPMsYK   susceptible form
QVPLRPMaYK   diminished response
QVPLRPaTYK   diminished response
aVPLRPMTYK   susceptible form
QaPLRPMTYK   susceptible form
QVaLRPMTYK   susceptible form
QVPaRPMTYK   susceptible form
QVPLRaMTYK   susceptible form
QVPLRPMTaK   susceptible form
QVPLRPMTYa   susceptible form
Species (MHC/HLA human(A*0301)

Variant Details

Showing all: 13 variant(s).


Variant ID.  739
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QiPLRPMTYK
Mutations V/I
Epitope Location V2I
HXB2 Location V74I
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Variant found in the plasma before CTL infusion in the patient. The variant induced the same amount of lysis as the wt epitope.


Variant ID.  740
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLaPMTYK
Mutations R/A
Epitope Location R5A
HXB2 Location R77A
Mutation Type DR: diminished response
Method Chromium-release assay
Note Artificial variant that required a 10ˆ4 to 10ˆ5 increase in peptide concentration to induce same amount of lysis as the wt epitope.


Variant ID.  741
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLgPMTYK
Mutations R/G
Epitope Location R5G
HXB2 Location R77G
Mutation Type DR: diminished response
Method Chromium-release assay
Note Artificial variant that required an increase in peptide concentration to induce same amount of lysis as the wt epitope.


Variant ID.  742
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLgPMsYK
Mutations R/G T/S
Epitope Location R5G T8S
HXB2 Location R77G T80S
Mutation Type SF: susceptible form
Method Chromium-release assay
Note The second mutation restored the ability of this variant to sensitize target cells for lysis.


Variant ID.  743
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMaYK
Mutations T/A
Epitope Location T8A
HXB2 Location T80A
Mutation Type DR: diminished response
Method Chromium-release assay
Note Artificial variant that required a 10ˆ4 to 10ˆ5 increase in peptide concentration to induce same amount of lysis as the wt epitope.


Variant ID.  744
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPaTYK
Mutations M/A
Epitope Location M7A
HXB2 Location M79A
Mutation Type DR: diminished response
Method Chromium-release assay
Note Artificial variant that required a 10-100-fold increase in peptide concentration to induce same amount of lysis as the wt epitope.


Variant ID.  745
Epitope Seq.  QVPLRPMTYK
Variant Seq.  aVPLRPMTYK
Mutations Q/A
Epitope Location Q1A
HXB2 Location Q73A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.


Variant ID.  746
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QaPLRPMTYK
Mutations V/A
Epitope Location V2A
HXB2 Location V74A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.


Variant ID.  747
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVaLRPMTYK
Mutations P/A
Epitope Location P3A
HXB2 Location P75A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.


Variant ID.  748
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPaRPMTYK
Mutations L/A
Epitope Location L4A
HXB2 Location L76A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.


Variant ID.  749
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRaMTYK
Mutations P/A
Epitope Location P6A
HXB2 Location P78A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.


Variant ID.  750
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMTaK
Mutations Y/A
Epitope Location Y9A
HXB2 Location Y81A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.


Variant ID.  751
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMTYa
Mutations K/A
Epitope Location K10A
HXB2 Location K82A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Artificial variant that induced the same amount of lysis as the wt epitope.

References

Koenig1995 S. Koenig, A. J. Conley, Y. A. Brewah, G. M. Jones, S. Leath, L. J. Boots, V. Davey V, G. Pantaleo, J. F. Demarest, and C. Carter. Transfer of HIV-1-Specific Cytotoxic T Lymphocytes to an AIDS Patient Leads to Selection for Mutant HIV Variants and Subsequent Disease Progression. Nat. Med., 1(4):330-336, 1995. PubMed ID: 7585062. Show all entries for this paper.


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