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Found 1 matching record:

Displaying record number 981

HXB2 Location  Nef(73-82)   Nef Epitope Map
View variants at this location
Epitope QVPLRPMTYK   Epitope Alignment
Variants
QVPLRPMTsr   diminished HLA binding or increased off-rate
{r*}QVPLRPMTYK{g}   inferred escape; processing
Species (MHC/HLA human(A11)

Variant Details

Showing all: 2 variant(s).


Variant ID.  128
Epitope Seq.  QVPLRPMTYK
Variant Seq.  QVPLRPMTsr
Mutations K/R Y/S
Epitope Location K10R Y9S
HXB2 Location K82R Y81S
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Chromium-release assay, HLA binding
Note The epitope QVPLRPMTYK was entirely conserved in 9 isolates from the donor who did not recognize this epitope. QVPLRPMTsr substitutions resulted in a very low binding to HLA-A11.


Variant ID.  2283
Epitope Seq.  {T*}QVPLRPMTYK{A}
Variant Seq.  {r*}QVPLRPMTYK{g}
Mutations A/G T/R
Epitope Location A+1G T-2R
HXB2 Location A83G T71R
Mutation Type IE: inferred escape
P: processing
Method Chromium-release assay, HLA binding
Note The epitope QVPLRPMTYK was entirely conserved in 9 isolates from the donor who did not recognize this epitope, whereas there were flanking mutations T71R and A83G, suggesting a processing escape.

References

Couillin1994 I. Couillin, B. Culmann-Penciolelli, E. Gomard, J. Choppin, J. P Levy, J. G. Guillet, and S. Sarasgosti. Impaired Cytotoxic T Lymphocyte Recognition Due to Genetic Variations in the Main Immunogenic Region of the Human Immunodeficiency Virus 1 NEF Protein. J. Exp. Med., 180:1129-11234, 1994. HIV-1 HLA-A11 and -B18 restricted epitopes were sequenced from donors who do and do not express the HLA-A11 and B18 molecule. Selective variations were only detected in virus isolated from individuals expressing the appropriate HLA type. Variant peptides with single substitutions within the minimal epitope did not always completely abrogate HLA binding, suggesting that multiple alterations within a particular epitope may need to accumulate during disease progression to allow viral escape. PubMed ID: 7520468. Show all entries for this paper.

Goulder1997e P. Goulder, D. Price, M. Nowak, S. Rowland-Jones, R. Phillips, and A. McMichael. Co-Evolution of Human Immunodeficiency Virus and Cytotoxic T-Lymphocyte Responses. Immunol. Rev., 159:17-29, 1997. PubMed ID: 9416500. Show all entries for this paper.


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