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Found 1 matching record:

Displaying record number 975

HXB2 Location  Nef(73-82)   Nef Epitope Map
View variants at this location
Epitope QVPLRPMTYK   Epitope Alignment
Variants
{k*}QVPLRPMTYK{g}   escape documented in this paper; processing
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2323
Epitope Seq.  {T*}QVPLRPMTYK{A}
Variant Seq.  {k*}QVPLRPMTYK{g}
Mutations A/G T/K
Epitope Location A+1G T-2K
HXB2 Location A83G T71K
Mutation Type E: escape documented in this paper
P: processing
Note Mutations in Nef that flank this epitope, Thr71Lys and Ala83Gly, may account for an observed loss of CTL reactivity, with escape due to the introduction of proteasome processing defects.

References

Chassin1999 D. Chassin, M. Andrieu, W. Cohen, B. Culmann-Penciolelli, M. Ostankovitch, D. Hanau, and J. G. Guillet. Dendritic Cells Transfected with the nef Genes of HIV-1 Primary Isolates Specifically Activate Cytotoxic T Lymphocytes from Seropositive Subjects. Eur. J. Immunol., 29:196-202, 1999. PubMed ID: 9933101. Show all entries for this paper.


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