HIV molecular immunology database


Search the Epitope Variant and Escape Mutation Database


Found 1 matching record:

Displaying record number 971

HXB2 Location  Nef(71-81)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPMTY   Epitope Alignment
RPQVPLRPMTf   susceptible form
Species (MHC/HLA human(B35)

Variant Details

Showing all: 1 variant(s).

Variant ID.  682
Variant Seq.  RPQVPLRPMTf
Mutations Y/F
Epitope Location Y11F
HXB2 Location Y81F
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Variant found in 9/10 B35+ individuals and in 0/3 B35- individuals. Equally susceptible to CTLs and binds equally well to B35 as the wt.


Kawana1999 A. Kawana, H. Tomiyama, M. Takiguchi, T. Shioda, T. Nakamura, and A. Iwamoto. Accumulation of Specific Amino Acid Substitutions in HLA-B35-Restricted Human Immunodeficiency Virus Type 1 Cytotoxic T Lymphocyte Epitopes. AIDS Res. Hum. Retroviruses, 15:1099-1107, 1999. PubMed ID: 10461830. Show all entries for this paper.

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