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Found 1 matching record:

Displaying record number 864

HXB2 Location  gp160(770-780)   gp160 Epitope Map
View variants at this location
Epitope RLRDLLLIVTR   Epitope Alignment
Variants
RLRDfiLIVTR   diminished response; subtype-specific susceptible form
SLRDLLLIVTR   diminished response; subtype-specific susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 2 variant(s).


Variant ID.  106
Epitope Seq.  RLRDLLLIVTR
Variant Seq.  RLRDfiLIVTR
Mutations L/F L/I
Epitope Location L5F L6I
HXB2 Location L774F L775I
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C, CRF01_AE
Method Chromium-release assay
Note The consensus peptide of clade B is RLRDLLLIVTR. The consensus peptide of clades A, C and E is RLRDFILIVTR and it is less reactive.


Variant ID.  107
Epitope Seq.  RLRDLLLIVTR
Variant Seq.  SLRDLLLIVTR
Mutations R/S
Epitope Location R1S
HXB2 Location R770S
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype D
Method Chromium-release assay
Note The consensus peptide of clade B is RLRDLLLIVTR. The consensus peptide of clade D is SLRDLLLIVTR and it is less reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


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