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HIV Molecular Immunology Database

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Found 1 matching record:

Displaying record number 640

HXB2 Location  Env(42-52)   Env Epitope Map
View variants at this location
Epitope VPVWKEATTTL   Epitope Alignment
Variants
VPVWKEAdTTL   subtype-specific susceptible form
VPVWrdAdTTL   subtype-specific susceptible form
VPVWKdAeTTL   subtype-specific susceptible form
Species (MHC/HLA human(B35)

Variant Details

Showing all: 3 variant(s).


Variant ID.  102
Epitope Seq.  VPVWKEATTTL
Variant Seq.  VPVWKEAdTTL
Mutations T/D
Epitope Location T8D
HXB2 Location T49D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype C
Method Chromium-release assay
Note VPVWKEATTTL is the consensus sequence for clades B and D.VPVWKEAdTTL is the consensus sequence for clade C and it is cross-reactive.


Variant ID.  103
Epitope Seq.  VPVWKEATTTL
Variant Seq.  VPVWrdAdTTL
Mutations K/R E/D T/D
Epitope Location K5R E6D T8D
HXB2 Location K46R E47D T49D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype C
Method Chromium-release assay
Note VPVWKEATTTL is the consensus sequence for clades B and D. VPVWrdAdTTL is the consensus sequence for clade E and even with three substitutions still retains some cross-reactivity.


Variant ID.  2932
Epitope Seq.  VPVWKEATTTL
Variant Seq.  VPVWKdAeTTL
Mutations E/D T/E
Epitope Location E6D T8E
HXB2 Location E47D T49E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype C
Method Chromium-release assay
Note VPVWKEATTTL is the consensus sequence for clades B and D. VPVWKdAeTTL is the consensus sequence for clade A and it is cross-reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


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