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Displaying record number 63094

HXB2 Location  Tat(39-47)   Tat Epitope Map
View variants at this location
Epitope ITKGLGISY   Epitope Alignment
Variants
ITKGLGISh   susceptible form
ITKGLdISY   escape documented in this paper
IkKGLGISY   escape documented in this paper
Species (MHC/HLA human

Variant Details

Showing all: 3 variant(s).


Variant ID.  5116
Epitope Seq.  ITKGLGISY
Variant Seq.  ITKGLGISh
Mutations Y/H
Epitope Location Y9H
HXB2 Location Y47H
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Peptide titration
Note The autologous variant ITKGLGISh was defined by authors as the epitope sequence observed at the earliest plasma sample time point from subject MM48.


Variant ID.  5117
Epitope Seq.  ITKGLGISY
Variant Seq.  ITKGLdISY
Mutations G/D
Epitope Location G6D
HXB2 Location G44D
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Peptide titration
Note The autologous variant ITKGLdISY evolved to dominate the quasispacies, and was recognized less well than ITKGLGISh, the autologous index epitope, by PBMCs from subject MM48 sampled at time points around the time of response decline, indicating escape.


Variant ID.  5118
Epitope Seq.  ITKGLGISY
Variant Seq.  IkKGLGISY
Mutations T/K
Epitope Location T2K
HXB2 Location T40K
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Peptide titration
Note The autologous variant IkKGLGISY evolved to dominate the quasispacies, and was recognized less well than ITKGLGISh, the autologous index epitope, by PBMCs from subject MM48 sampled at time points around the time of response decline, indicating escape.

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.


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