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Displaying record number 63094

HXB2 Location Tat(39-47) Tat Epitope Map
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ITKGLGISY

`ITKGLGISh`		susceptible form
`ITKGLdISY`		escape documented in this paper
`IkKGLGISY`		escape documented in this paper

Species (MHC/HLA) human

Variant Details

Showing all: 3 variant(s).

Variant ID.	`5116`
Epitope Seq.	`ITKGLGISY`
Variant Seq.	`ITKGLGISh`
Mutations	Y/H
Epitope Location	Y9H
HXB2 Location	Y47H
Mutation Type	SF: susceptible form
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Peptide titration
Note	The autologous variant ITKGLGISh was defined by authors as the epitope sequence observed at the earliest plasma sample time point from subject MM48.

Variant ID.	`5117`
Epitope Seq.	`ITKGLGISY`
Variant Seq.	`ITKGLdISY`
Mutations	G/D
Epitope Location	G6D
HXB2 Location	G44D
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Peptide titration
Note	The autologous variant ITKGLdISY evolved to dominate the quasispacies, and was recognized less well than ITKGLGISh, the autologous index epitope, by PBMCs from subject MM48 sampled at time points around the time of response decline, indicating escape.

Variant ID.	`5118`
Epitope Seq.	`ITKGLGISY`
Variant Seq.	`IkKGLGISY`
Mutations	T/K
Epitope Location	T2K
HXB2 Location	T40K
Mutation Type	E: escape documented in this paper
Epitope Subtype	B
Variant Subtype	B
Method	CD8 T-cell Elispot - IFNy, Longitudinal study, Peptide titration
Note	The autologous variant IkKGLGISY evolved to dominate the quasispacies, and was recognized less well than ITKGLGISh, the autologous index epitope, by PBMCs from subject MM48 sampled at time points around the time of response decline, indicating escape.

References

Turnbull2009 Emma L. Turnbull, MaiLee Wong, Shuyi Wang, Xiping Wei, Nicola A. Jones, Karen E. Conrod, Diana Aldam, Jo Turner, Pierre Pellegrino, Brandon F. Keele, Ian Williams, George M. Shaw, and Persephone Borrow. Kinetics of Expansion of Epitope-Specific T Cell Responses During primary HIV-1 Infection. J. Immunol., 182(11):7131-7145, 1 Jun 2009. PubMed ID: 19454710. Show all entries for this paper.